埃索美拉唑与奥美拉唑治疗反流性食管炎临床对比观察

目的分析研讨埃索美拉唑与奥美拉唑治疗反流性食管炎的临床效果。方法随机从本院2016年2月—2018年12月期间收治的反流性食管炎患者中抽取80例,按治疗方式分对照组(40例接受奥美拉唑治疗)和研究组(40例接受埃索美拉唑治疗),比较治疗效果。结果研究组治疗疗效95.00%高于对照组75.00%,差异有统计学意义(P<0.05)。治疗前组间食管动力学指标差异无统计学意义(P>0.05),治疗后,研究组蠕动性收缩比、立位反流时间百分比、卧位反流时间百分比低于对照组,肌静息压力高于对照组,差异有统计学意义(P<0.05)。治疗前症状评分差异无统计学意义(P>0.05),治疗后,研究组症状评分低于对照组,差异有统计学意义(P<0.05)。研究组不良反应总发生率5.00%低于对照组7.50%,但数据差异无统计学意义(P>0.05)。结论埃索美拉唑治疗反流性食管炎,其疗效比奥美拉唑所获疗效更良好,患者症状、食管动力学指标等改善明显。

Comparison of Clinical Effect of Esomeprazole and Omeprazole in Treatment of Reflux Esophagitis

Objective To analyze the clinical effect of esomeprazole and omeprazole in the treatment of reflux esophagitis.Methods 80 cases of patients were selected from patients with reflux esophagitis and who treated in the hospital from February 2016 to December 2018 were randomly selected,and the patients were divided into the control group(40 patients were received omeprazole)and the study group(40 cases were received the esomeprazole).The treatment effect of two groups were compared.Results The therapeutic effect in the study group was 95.00%,which was higher than that in the control group of 75.00%,the difference was statistically significant(P<0.05).There was no statistically significant difference in esophageal kinetics between the groups before treatment(P>0.05).After treatment,the peristaltic contraction ratio,the percentage of orthostatic reflux time and the percentage of recumbent reflux time in the study group were lower than those in the control group,and the muscle resting pressure was higher than that in the control group,the differences were statistically significant(P<0.05).There was no statistically significant difference in symptom score before treatment(P>0.05).After treatment,the symptom score in the study group was lower than that in the control group,the difference was statistically significant(P<0.05).The total incidence of adverse reactions in the study group was 5.00%,which was lower than that in the control group of 7.50%,but the difference was no statistically significant(P>0.05).Conclusion The esomeprazole is more effective than omeprazole in the treatment of reflux esophagitis.The symptoms and esophageal dynamics of the patients are improved.