Brazilian Experience Using High-Dose Sequential Chemotherapy Followed by Autologous Hematopoietic Stem Cell Transplantation for Relapsed or Refractory Hodgkin Lymphoma |
| |
| Authors: | Bruno K.L. Duarte Isabella Valente Afonso C. Vigorito Francisco J.P. Aranha Gislaine Oliveira-Duarte Eliana C.M. Miranda Irene Lorand-Metze Katia B. Pagnano Marcia Delamain José F. Marques Junior Silvia R. Brandalise Márcio Nucci Carmino A. De Souza |
| |
| Affiliation: | 1. Bone Marrow Transplantation Unit, University of Campinas – UNICAMP, São Paulo, Brazil;2. Vera Cruz Hospital, Campinas, São Paulo, Brazil;3. Boldrini Children''s Cancer Center, Campinas, São Paulo, Brazil;4. Federal University of Rio de Janeiro, UFRJ, Brazil |
| |
| Abstract: | PurposeWe evaluate the effectiveness and toxicity of high-dose sequential chemotherapy (HDS) as salvage therapy in patients with advanced-stage Hodgkin lymphoma.Patients and MethodsWe performed a retrospective analysis on 77 patients receiving HDS between 1998 and 2006. Patients enrolled were in disease progression or relapsed disease, or did not achieve a complete remission after first-line treatment. HDS consisted of the sequential administration of cyclophosphamide and granulocyte colony-stimulating factor with stem cell harvesting, followed by methotrexate plus vincristine and etoposide.ResultsThe majority of patients had stage III/IV (64%) and B symptoms (71.4%). Disease status improvement after HDS was observed in 24 of 57 patients (42%) previously in disease progression or relapse. HDS-related deaths occurred in 8 of 77 patients (10.4%). Four patients (5.2%) developed acute myeloid leukemia/myelodysplastic syndrome. Overall, disease-free and progression-free survival was 27%, 57%, and 25%, respectively.ConclusionDespite the treatment-related mortality, HDS is feasible, with satisfactory response rates, even in patients with poor prognosis. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
