| 口服长效抗疟药的实验研究——Ⅱ.羟基喹哌对鼠疟的防治效果 |
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| 引用本文： | 瞿逢伊,黄文锦,王丽琴. 口服长效抗疟药的实验研究——Ⅱ.羟基喹哌对鼠疟的防治效果[J]. 药学学报, 1981, 16(4): 298-301 |
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| 作者姓名： | 瞿逢伊 黄文锦 王丽琴 |
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| 作者单位： | 第二军医大学寄生虫学教研室 上海(瞿逢伊，黄文锦)，第二军医大学寄生虫学教研室 上海(王丽琴) |
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| 摘 要： | 在前文肯定喹哌抗疟作用的基础上,为了探讨喹哌化学结构与抗疟效果的关系,我校抗疟药合成组合成了多种衍生物,在筛选中发现羟基喹哌抗疟效果较好,现将其对伯氏鼠疟原虫(Plasmodium berghei Vincke et Lips,1948)的实验防治结果报道如下。
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| 收稿时间： | 1980-01-21 |
EXPERIMENTAL STUDIES ON ORALLY ADMINIS TERED LONG-ACTING ANTIMALARIALS.——Ⅱ. OBSERVATIONS ON THERAPEUTIC AND PROPHYLACTIC EFFECT OF HYDROXYPIPERAQUINE ON RODENT MALARIA |
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| Qu Fengyi ,Huang Wenjin and Wang Liqin. EXPERIMENTAL STUDIES ON ORALLY ADMINIS TERED LONG-ACTING ANTIMALARIALS.——Ⅱ. OBSERVATIONS ON THERAPEUTIC AND PROPHYLACTIC EFFECT OF HYDROXYPIPERAQUINE ON RODENT MALARIA[J]. Acta pharmaceutica Sinica, 1981, 16(4): 298-301 |
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| Authors: | Qu Fengyi Huang Wenjin Wang Liqin |
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| Affiliation: | Qu Fengyi (Chu Eeng-i),Huang Wenjin and Wang Liqin |
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| Abstract: | This paper reports the results of the experimental studies on antimalarial effect of hydroxypiperaquine against rodent malaria (Plasimodium berghei). The results obtained showed that the PD50 of hydroxypiperaquine and its phosphate was much larger than that of piperaquine. The CD50 and the resistance index of hydroxypiperaquine and it 7 salts were listed. In comparisons of the therapeutic activities of hydroxypiperaquine, piperaquine and chloroquine at the peak parasitaemia, the former 2 drugs showed almost the same effect, whereas chloroquine was less effective in terms of survival rate of the treated mice and the infection rate of erythrocytes. |
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