| 阿司匹林-烟酰胺-锌络合物荷H22肝癌小鼠作用的研究 |
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| 引用本文： | 张建武,蒲其松,陈斗佳.阿司匹林-烟酰胺-锌络合物荷H22肝癌小鼠作用的研究[J].四川生理科学杂志,2012,34(4):148-149. |
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| 作者姓名： | 张建武 蒲其松 陈斗佳 |
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| 作者单位： | 1. 川北医学院药理教研室,四川 南充,637100
2. 遵义医学院附属医院血液科,贵州 遵义,563000 |
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| 基金项目： | 川北医学院苗圃(08)基-12 |
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| 摘 要： | 目的：研究阿司匹林-烟酰胺-锌络合物（商品名：佛立沙，wuY）抗肿瘤作用。方法：在小鼠腋皮下接种H22肿瘤细胞后，每日igwUY1次，连续给药9d，第10d处死小鼠，剥取瘤块称重并计算抑瘤率。结果：wUY40mg·kg-1对小鼠H22抑制率为32．83％，与模型组比较，wUY有显著的抑制小鼠H22移植瘤的作用（P〈0．05），结论：wUY对小鼠H22移植瘤有明显的抑制作用。
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| 关 键 词： | 阿司匹林-烟酰胺-锌络合物 H22 细胞 抗肿瘤作用 |
Antitumor effect of aspirin-niacinamide-zinc complex on H22 hepatoma-bearing mice |
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| Zhang Jian-wu
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Pu Qi-song
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Chen Dou-jia.Antitumor effect of aspirin-niacinamide-zinc complex on H22 hepatoma-bearing mice[J].Sichuan Journal of Physiological Sciences,2012,34(4):148-149. |
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| Authors: | Zhang Jian-wu Pu Qi-song Chen Dou-jia |
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| Institution: | 1.Department of Pharmacology,North Sichuan Medical College,Sichuan Nanchong 637100; 2.Department of Hematology,The Affiliated Hospital of Zunyi Medical College,Guizhou Zunyi 563000) |
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| Abstract: | Objective： To investigate the antitumor effect of aspirin-niacinamide-zinc complex （WUY）on H22 hepatoma-bearing mice. Methods： By inoculating subcutaneously with the tumor cells of H22, mice were administered immediately by gavage once a day for 9 days. 24 h later, all the mice were killed to get their transplanted tumors to weigh and calculate the inhibitory rate of the tumor. Results： The rate of tumor inhibition of WUY 40 mg · kg-1 against H22 in vivo was 32. 83%. Compared with model group, WUY could obviously inhibit the growth of H22 in vivo （P〈0.05）. Conclusions： WUY can obviously inhibit the growth of H22 in vivo. |
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| Keywords: | Aspirin-niacinamide-zinc complex Hepatoma Antitumor |
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