| 中国北方汉族人细胞色素P4501 A1基因MspⅠ多态性的研究 |
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| 引用本文： | 刘振华,刘平,邵明,陈彪.中国北方汉族人细胞色素P4501 A1基因MspⅠ多态性的研究[J].解剖学研究,2002,24(1):6-8. |
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| 作者姓名： | 刘振华 刘平 邵明 陈彪 |
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| 作者单位： | 1. 第一军医大学珠江医院神经内科,广州,510282
2. 北京市宣武医院神经内科 |
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| 基金项目： | 北京市卫生局重点学科资助项目"老年神经退行性疾病的基础与临床研究";北京市科委科技新星计划资助项目(954812600) |
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| 摘 要： | 目的 探讨中国北方汉族人细胞色素P(cytochromeP ,CYP) 4 5 0 1A1基因MspⅠ多态性。方法 用聚合酶链反应 限制性片段长度多态性 (PCR RFLP)技术 ,分析了 172名北方汉族正常健康成人CYP1A1基因 3′端限制性内切酶MspⅠ位点的3种基因型 (A、B、C)的分布频率。结果 MspⅠ等位基因m1、m2分别占 6 0 8%、39 2 %。MspⅠ基因型A占 34 9% ,基因型B占 5 1 7% ,基因型C占 13 4 %。结论 本研究结果提示中国北方汉族人解毒酶CYP1A1基因存在MspⅠ多态性。
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| 关 键 词： | 细胞色素P4501A1 等位基因 基因多态 |
| 修稿时间： | 2001年10月10 |
Study in genetic polymorphisms of cytochrome P4501A1 among Hans in North China |
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| Liu Zhenhua,Liu Ping,Shao Ming,Chen Biao.Study in genetic polymorphisms of cytochrome P4501A1 among Hans in North China[J].Anatomy Research,2002,24(1):6-8. |
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| Authors: | Liu Zhenhua Liu Ping Shao Ming Chen Biao |
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| Institution: | Liu Zhenhua,Liu Ping,Shao Ming,Chen Biao.Department of Neurology,Zhujiang Hospital,The First Military Medical University,Guangzhou 510282,China |
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| Abstract: | Objective To assess the MspⅠ polymorphisms of CYP1A1 among Hans in North China.Methods Using polymerase chain reaction restriction fragment length polymorphism(PCR RFLP),three genotypes A,B and C in 3′ flanking region of CYP1A1 were studied in 172 Hans in North China.Results The frequencies of genotype A,B and C were 34.9%,51.7% and 13.4%,respecitively,while allele m1 and m2 were 60.8% and 39.2%,respectively.Conclusion Our results suggest that CYP1A1 has Msp Ⅰ polymorphisms among Hans in North China. |
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| Keywords: | Cytochrome P4501A1 Allele Genetic polymporphism |
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