3种5-HT3受体拮抗剂预防肝癌患者介入治疗后恶心呕吐的疗效比较

目的:通过测定中药制剂参芪扶正注射液中Cu、Zn、Mn、Se、Mo、Fe、Cr、Ni、V、Sn、Pb、Cd、Hg、As等14种微量元素的含量,探讨该中药注射液中元素的分布是否存在某种规律性.方法:微波消解法制备供试品,电感耦合等离子体-质谱(ICP-MS)法测定.结果:参芪扶正注射液中Cu、Fe、Zn、Cr、Se的相对含量较高,有毒元素Pb、Cd、Hg、As中As含量接近美国FAD药品与功能性食品要求标准,Pb、Cd、Hg含量均明显低于最高限量.结论:测定结果为探讨中药制剂中微量元素与抗肿瘤作用的关系提供有用的数据.

Effects of ondansetron,granisetron,and tropisetron on vomiting caused by transcatheter arterial chemoembolization (TACE)

Objective:To compare the prophylactic efficacy of ondansetron,granisetron,and tropisetron on vomiting caused by TACE. Methods: 120 patients(with primary hepatocellular carcinoma) were randomly divided into four groups to receive ondanstron,granisetron,tropisetron via liver artery injection (n=30) and combined with metoclopramide as controls (n=30).The antiemetic efficacies were compared among the four groups for 5 consecutive days after TACE. Results:The effective rate of tropisetron group was significantly higher than that of the control group (P<0.05).Conclusion:Tropisetron is an effective antiemetic drug in controlling vomiting caused by TACE and should be advocated in clinical practice.