| 影响人工泪液中增稠剂粘度的因素 |
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| 引用本文： | 宋俊生,周立新.影响人工泪液中增稠剂粘度的因素[J].中国药科大学学报,1997,28(2):69-72. |
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| 作者姓名： | 宋俊生 周立新 |
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| 作者单位： | 南京药物研究所 |
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| 基金项目： | 国家自然科学基金青年基金 |
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| 摘 要： | 考察了离子强度、ｐＨ及不同防腐剂对人工泪液中常用的四种增稠剂，即甲基纤维素（ＭＣ）、羧甲基纤维素钠（ＣＭＣ－Ｎａ）、聚乙烯醇（ＰＶＡ）及羟丙甲基纤维素（ＨＰＭＣ）粘度的影响，并着重考察强光、高温对不同ｐＨ值ＨＰＭＣ溶液粘度的影响。结果表明，除ＣＭＣ－Ｎａ的粘度随离子强度的增加而降低外，粘度均较为稳定。
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| 关 键 词： | 人工泪液 粘度 甲基纤维素 羧甲基纤维素钠 聚乙烯醇 羟丙甲基纤维素 |
Viscosity of Artificial Tears and Its Stability |
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| Song Junsheng,Zhou Lixin,Hua Xin Nanjing Institute of Material Medic,Nanjing.Viscosity of Artificial Tears and Its Stability[J].Journal of China Pharmaceutical University,1997,28(2):69-72. |
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| Authors: | Song Junsheng Zhou Lixin Hua Xin Nanjing Institute of Material Medic Nanjing |
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| Institution: | Song Junsheng,Zhou Lixin,Hua Xin Nanjing Institute of Material Medica,Nanjing 210009 |
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| Abstract: | The viscosity of the ophthalmic solution is an important factor which influencs the quality of artificial tears, in this article, four kinds of viscous solution including methylcellulose(MC) sodium carboxymethyl cellulose(CMC Na) polyvinyl alcohol(PVA) and hydroxypropylmethyl cellulose(HPMC) were tested by such factors as ion strength pH preservatives light heat and acidity.In most cases, the viscosities were stable except CMC Na solution, which may be depressed as an increase in ion strength. |
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| Keywords: | Artificial tears Viscosity MC CMC Na PVA HPMC |
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