| 沙鼠短暂脑缺血再灌p53基因表达 |
| |
| 引用本文： | 谷文萍 杨期东 等. 沙鼠短暂脑缺血再灌p53基因表达[J]. 湖南医科大学学报, 2001, 26(2): 121-122 |
| |
| 作者姓名： | 谷文萍 杨期东 等 |
| |
| 作者单位： | [1]中南大学湘雅医院神经病学研究所，长沙410008 [2]中南大学湘雅医院神经病学研究所，长沙4 |
| |
| 摘 要： | 目的：研究脑缺血再灌后p53基因表达变化。方法：采用沙鼠短暂前脑缺血再灌损伤模型，应用Northern blot检测脑缺血再灌后不同时期额叶p53 mRNA表达。结果：沙鼠脑缺血6min，在再灌后6h p53 mRNA出现表达增加，持续至第3d（P＜0.05)。结论：沙鼠短暂脑缺血后，促凋亡基因p53存在持续高表达，其结果可能是启动细胞凋亡，导致缺血神经细胞损伤死亡。
|
| 关 键 词： | 脑缺血 p53基因 沙鼠 基因表达 再灌注损伤 |
Study on p53 gene expression following transient ischemia in the gerbil] |
| |
| W P Gu,Q D Yang,G J Xie. Study on p53 gene expression following transient ischemia in the gerbil][J]. Bulletin of Hunan Medical University, 2001, 26(2): 121-122 |
| |
| Authors: | W P Gu Q D Yang G J Xie |
| |
| Affiliation: | Institute of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China. |
| |
| Abstract: | OBJECTIVE: To study the expression of p53 gene after transient ischemia in the gerbil. METHODS: Northern blot was used to detect the expression of the p53 mRNA in the forebrain during different periods after post-ischemic reperfusion in the gerbil. RESULTS: The expression of p53 mRNA increased in the forebrain during the 6th hour to the 3rd day of reperfusion following 6 min of ischemia (P < 0.05). CONCLUSION: The high level expression of p53 might induce neuronal apoptosis after ischemia. |
| |
| Keywords: | |
| 本文献已被 维普 等数据库收录！ |
