| 接种卡介苗对热休克蛋白65-MUC1抗原肽融合蛋白抑瘤作用的影响 |
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| 引用本文： | 任淑萍,万敏,卫红飞,王莉,于永利,王丽颖.接种卡介苗对热休克蛋白65-MUC1抗原肽融合蛋白抑瘤作用的影响[J].中国免疫学杂志,2005,21(8):598-601. |
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| 作者姓名： | 任淑萍 万敏 卫红飞 王莉 于永利 王丽颖 |
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| 作者单位： | 1. 吉林大学基础医学院分子生物学教研室,长春,130021
2. 吉林大学基础医学院免疫学教研室,长春,130021 |
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| 基金项目： | 本课题为国家高科技“863”计划资助项目（2002AA214141） |
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| 摘 要： | 目的：探讨接种卡介苗对热休克蛋白65-MUC1抗原肽融合蛋白（HSP65-MUC1）所激发的抑瘤作用的影响。方法：给经卡介苗免疫后产生HSP65抗体的小鼠注射HSP65-MUC1融合蛋白3次，然后给小鼠接种MUC1阳性的B16肿瘤细胞，观察HSP65-MUC1融合蛋白对MUC1阳性的B16肿瘤细胞在已产生HSP65抗体的小鼠体内生长的抑制作用。结果：HSP65-MUC1能够显著抑制MUC1阳性的B16肿瘤细胞在已产生HSP65抗体小鼠体内的生长，HSP65-MUC1组小鼠的肿瘤重量和体积显著地低于PBS组。结论：接种卡介苗并不影响HSP65-MUC1所激发的对MUC1阳性B16肿瘤细胞生长的抑制作用。
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| 关 键 词： | 卡介苗 热休克蛋白 融合蛋白 MUC1抗原肽 免疫复合物 |
| 文章编号： | 1000-484X（2005）08-0598-04 |
| 收稿时间： | 2004-12-23 |
| 修稿时间： | 2004-12-23 |
Effects of BCG immunization on tumor suppression elicited by heat shock protein-MUC1 fusion protein |
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| REN Shu-ping,WAN Min,WEI Hong-fei,WANG Li,YU Yong-Li,WANG Li-Ying.Effects of BCG immunization on tumor suppression elicited by heat shock protein-MUC1 fusion protein[J].Chinese Journal of Immunology,2005,21(8):598-601. |
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| Authors: | REN Shu-ping WAN Min WEI Hong-fei WANG Li YU Yong-Li WANG Li-Ying |
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| Abstract: | Objective:To explore the effects of BCG immunization on the tumor suppression elicited by heat shock protein-MUC1 fusion protein(HSP-MUC1).Methods:Mice which produced anti-HSP65 antibodies through BCG immunization were injected with HSP-MUC1 three times and then transplanted with MUC1 positive B16 tumor cells to observe the tumor suppression effects elicited by HSP-MUC1.Results:The growth of MUC1 positive B16 tumor cells in mice which produced anti-HSP65 antibodies through BCG immunization was significantly suppressed.The tumor weight and tumor volume in mice from HSP-MUC1 immunization group was significantly less than that of PBS group.Conclusion:BCG immunization did not exert effects on tumor suppression effects elicited by HSP-MUC1. |
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| Keywords: | BCG Anti-HSP65 antibody HSP- MUC1 fusion protein Tumor suppression |
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