2型糖尿病患者血清Asprosin水平与颈动脉内中膜厚度的关系

目的: 探讨2型糖尿病患者血清Asprosin水平与颈动脉内中膜厚度(carotid intima media thickness, CIMT)的关系。方法: 选取2型糖尿病患者99例，根据2011年《血管超声检查指南》标准，分为2型糖尿病合并CIMT增厚(CIMT≥1.0 mm)患者46例(CIMT增厚组)，2型糖尿病CIMT正常(CIMT＜1.0 mm)患者53例(CIMT正常组)。检测人体测量指标及生化参数，采用ELISA法检测受试者血清Asprosin浓度。计算致动脉粥样硬化指数(atherogenic index of plasma, AIP) 评估动脉粥样硬化程度。采用Spearman相关分析血清Asprosin与CIMT、AIP及生化指标的相关性，Logistic回归分析CIMT增厚的影响因素。结果： CIMT增厚组血清Asprosin明显高于CIMT正常组(P＜0.01)。相关分析显示，2型糖尿病患者血清Asprosin与CIMT、三酰甘油、AIP呈正相关(r分别为0.317、0.266、0.285，P＜0.01)，与载脂蛋白A呈负相关(r=-0.242，P=0.016)；2型糖尿病患者CIMT与年龄、病程、颈围、腰围、收缩压、Asprosin呈正相关(r分别为0.577、0.390、0.203、0.229、0.295、0.317，P＜0.05或P＜0.01)。Logistic回归分析结果显示，随着血清Asprosin升高，2型糖尿病患者CIMT增厚的患病风险增加。结论： Asprosin可能在2型糖尿病患者CIMT增厚的发生、发展中起一定的作用。

Relationship between the levels of serum Asprosin and carotid intima-media thickness in patients with type 2 diabetes mellitus

Objective: To investigate the relationship between serum asprosin levels and carotid intima media thickness (CIMT) in patients with type 2 diabetes mellitus (T2DM). Methods: A total of 99 patients with T2DM were enrolled in this study. According to the 2009 Guidelines for Vascular Ultrasound, all patients were divided into two groups, including 46 patients with thickening CIMT (CIMT≥1.0 mm, thickening CIMT group) and 53 patients with normal CIMT (CIMT＜1.0 mm, normal CIMT group). Clinical and biochemical parameters were tested and the serum asprosin was analyzed by ELISA. The atherosclerosis index of plasma (AIP) was calculated to assess the degree of atherosclerosis. Spearman correlation analysis was used to analyze the correlation between serum asprosin and CIMT, AIP and biochemical indicators. Logistic regression analysis was used to analyze the influencing factors of CIMT thickening. Results: The serum asprosin in the thickening CIMT group was higher than that of the normal CIMT group (P＜0.01). Correlation analysis showed that the serum asprosin of T2DM patients was positively correlated with CIMT, triglyceride and AIP (r=0.317, 0.266, 0.285, P＜0.01) and was negatively correlated with apolipoprotein A (r=-0.242, P =0.016); CIMT was positively correlated with age, duration, neck circumference, waist circumference, systolic blood pressure and asprosin (r=0.577, 0.390, 0.203, 0.229, 0.295, 0.317, P＜0.05 or P＜0.01). Logistic regression analyses demonstrated that as serum asprosin increases, the risk of CIMT thickening increases in patients with T2DM. Conclusion: Asprosin may play a role in the occurrence and development of CIMT thickening in T2DM patients. ［Key words］type 2 diabetes mellitus; asprosin; carotid intima-media thickness; atherosclerosis