酒精所致的精神和行为障碍患者血浆非酶抗氧化物浓度的变化

目的:探讨酒精所致的精神和行为障碍患者血浆非酶抗氧化物浓度变化及其与患者精神病性症状的关系。方法:运用酒精使用障碍筛查量表(AUDIT)和简明精神病量表(BPRS)对患者进行评定;使用全自动生化仪测定研究组(44例)和对照组(46例)血浆白蛋白、总胆红素以及尿酸的浓度,采用成对样本t检验比较两组上述指标的差异;对研究组相关因素进行单因素及多因素分析。结果:研究组血浆中白蛋白[(42.87±4.42)g/L和(44.89±3.00)g/L,P<0.05]水平低于对照组;与对照组[(11.97±5.51)μmol/L和(328.39±75.18)μmol/L]比较,研究组[(26.71±17.31)μmol/L和(397.93±107.41)μmol/L]血浆中总胆红素和尿酸水平明显升高,差异有统计学意义(P<0.01);研究组患者精神病性症状总分与血浆尿酸水平(r=0.339,P<0.01)呈正相关。回归分析结果显示:研究组患者尿酸水平进入以精神病性症状总分为因变量的回归方程(t=2.332,P<0.05)。结论:非酶抗氧化物可能在酒精所致的精神和行为障碍的发病过程中起一定作用,尿酸可能与患者的精神病性症状有关。

Alterations of Plasma Non-enzyme Antioxidants Levels in Patients With Alcohol-induced Psychiatric and Behavioral Disorders

Objective:To investigate the plasma non-enzyme antioxidants levels in alcohol-induced psychiatric and behavioral disorders patients,and explore the correlation between the plasma non-enzyme antioxidants levels and the psychotic symptoms.Methods:44 alcohol-induced psychiatric and behavioral disorders patients and 46 normal subjects were recruited in the present study.Serum levels of non-enzyme antioxidants were determined with enzyme-linked immune sorbent assay(ELISA).The brief psychiatric rating scale(BPRS)and the alcohol use disorders identification test(AUDIT)were used to assess the psychotic symptoms and severity of alcohol dependence of the subjects,then employing SPSS22.0 for t-test,correlative analysis and regressive analysis.Results:The serum level of albumin[(42.87±4.42)g/L vs(44.89±3.00)g/L,P<0.05]was significantly lower in alcohol-induced psychiatric and behavioral disorders than that of normal control.In study group[(26.71±17.31)μmol/L and(397.93±107.41)μmol/L],the total bilirubin and uric acid levels were lower than those of the normal control group[(11.97±5.51)μmol/L and(328.39±75.18)μmol/L].Total score of psychotic symptoms were positively correlated with the uric acid levels(r=0.339,P<0.01).Regression analysis showed that the uric acid levels entered into the regression equation.(t=2.332,P<0.05).Conclusion:The non-enzyme antioxidants might be involved in the pathophysiology of with alcohol-induced psychiatric and behavioral disorders,The uric acid will exert significant effects on the psychotic symptoms.