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Profilin 1, negatively regulated by microRNA-19a-3p,serves as a tumor suppressor in human hepatocellular carcinoma
Authors:Zheyuan Wang  Zhiheng Shi  Lu Zhang  Huihan Zhang  Yawu Zhang
Affiliation:1. Department of General Surgery II, Lanzhou University Second Hospital, Lanzhou 730030, Gansu Province, China;2. Beijing RDFZ Chaoyang Branch School, Beijing 100028, China
Abstract:Profilin 1 (PFN1) is a critical actin-regulatory protein; however, its functional role in hepatocellular carcinoma (HCC) progression remains to be further elucidated. In the present study, we observed that the expression levels of PFN1 were significantly decreased in HCC tissues and cell lines. Low PFN1 expression was significantly correlated with aggressive clinicopathological characteristics and poor prognosis of HCC patients. Further in vitro experiments demonstrated that overexpression of PFN1 remarkably inhibited the proliferation, migration, invasion and EMT of HCC cells. Moreover, we also found that PFN1 was a direct target gene of miR-19a-3p, and in HCC tissues, and there was a significantly inverse correlation between PFN1 mRNA and miR-19a-3p expression. Collectively, our results showed that PFN1 functions as a tumor suppressor in HCC, and might serve as a diagnostic and therapeutic target for HCC patients.
Keywords:Hepatocellular carcinoma  Profilin 1  Epithelial-mesenchymal transition  microRNA-19a-3p
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