白花蛇舌草提取物逆转结肠癌细胞5-Fu耐药的作用

目的探讨大容量双肺灌洗治疗尘肺病的临床效果。方法对220例不同期别的尘肺病患者，在静脉复合麻醉下行双腔支气管插管，双肺成功隔离后，一侧肺纯氧通气，另一侧肺采用灌洗液反复灌洗，于灌洗前及灌洗后分别测定血气、肺功能，并观察术后病人临床症状改善情况。结果220例成功进行大容量双肺灌洗，术中顺利，术后临床症状明显减轻，无明显术后并发症。灌洗治疗后动脉血氧分压、肺通气功能与治疗前对比有统计学意义（P〈O．05）；相反，动脉血二氧化碳分压、肺弥散功能灌洗治疗前后均无统计学意义（P〉0．05）。结论大容量双肺灌洗治疗尘肺病是一种安全、有效的科学方法，值得临床推广应用。

Clinical Observation on Therapy of Pneumoconiosis with Massive Whole Lung Lavage

Objective To explore the clinical outcomes of Massive whole lung lavage for the therapy of pneumoconiosis. Methods 220 patients with pneumoconiosis at various stage were performed double lumen endotracheal intubation under the condition of combined intravenous anesthesia, and the bilateral lungs were successfully isolated from each other. Oxygen was carried out to one lateral lung and repeated lavage was meanwhile conducted to the other lateral lung. In the end, both the bilateral lungs were given lavage. Blood gas and lung function were detected before and after lavage, and observing clinical symptom of postoperative patients. Results Successful bilateral lung lavage was conducted in the 220 patients without obvious postoperative complications. The change in arterial partial pressure of oxygen （PaO2） and lung ventilation function was statistically significant, compared between before and after whole lung lavage （P〈0.05）. On the contrary, there were no obvious differences in arterial partial pressure of carbon dioxide （PaCO2） and lung diffuse function between before and after lavage （P〉0.05）; Conclusion Massive Whole lung lavage is effective on pneumoconiosis with safety.