Effect of ketotifen on acute gastric lesions and gastric secretion in rats. |
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| Authors: | S Okabe S Nakaji M Tachibana |
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| Institution: | Department of Applied Pharmacology, Kyoto Pharmaceutical University, Japan. |
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| Abstract: | Ketotifen, a histamine H1-receptor antagonist and mast cell stabilizer, significantly protected the rat gastric mucosa against lesions induced by necrotizing agents, histamine or compound 48/80. The agent significantly inhibited the basal gastric acid secretion, but had little or no effect on the histamine-stimulated secretion. The mucosal protective effect was observed even at a dose that had little or no effect on gastric acid secretion, suggesting that ketotifen exhibits so-called cytoprotective activity. |
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