高氧液对外伤性视神经损伤的作用

目的 分析外伤性视神经损伤后视觉诱发电位（VEP）变化规律及VEP检测外伤性视神经损伤的作用，并评价高氧液对外伤性视神经损伤的治疗价值。方法 将84例外伤性视神经损伤患者分为37例治疗组（高氧液治疗组）和47例对照组，分别于第1，7，14，21天进行VEP检查，分析比较振幅、潜伏期、视力变化情况及最后治疗效果。结果 伤后1～7d已开始出现VEP振幅下降，7～14d达峰值，21d已明显减轻；治疗组VEP异常的程度明显低于对照组（P〈0．05）；视力和预后均明显好于对照组（P〈0．05）；VEP异常程度越重，病情越重，预后越差。结论 高氧液对治疗外伤性视神经损伤有显著疗效，VEP是检测并评价外伤性视神经损伤疗效的有效方法。

Therapeutic effect of hyperxia liquid on posttraumatic optic nerve injuries

Objective To analyze the characteristics of visual evoked potential (VEP) and the role of VEP in detecting posttraumatic optic nerve injury and evaluate the value of hyperxia liquid in treatment of posttraumatic optic nerve injury. Methods A total of 84 patients with optic nerve injury were divided into control group (n=47, received the general treatments) and treatment group (n=37, treated with hyperxia liquid on the basis of the general treatments) that were monitored regularly by VEP at days 1, 7, 14 and 21 respectively after treatment to analyze and compare latency, amplitudes, visual acuity and treatment result. Results After injury, abnormality of VEP occurred at days 1-7, reached the peak at days 7-14, and then markedly relieved at day 21. Compared with control group, degree of VEP abnormality was significantly lower (P<0.05), with better visual acuity and prognosis (P<0.05) in treatment group. Severer abnormality of VEP and diseases would beget poorer prognosis. Conclusions Hyperxia liquid is effective in treatment of posttraumatic optic nerve injury. Early posttraumatic optic nerve injury can be detected effectively by VEP.