The interaction of tetrahydroisoquinoline derivatives with antinociceptive action of morphine and oxotremorine in mice |
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| Authors: | Vetulani J. Pavone F. Przewłocka B. Borghi V. Nalepa I. |
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| Affiliation: | (1) Department of Biochemistry, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland, PL;(2) Institute of Neuroscience, C.N.R., Psychobiology and Psychopharmacology, Rome, Italy, IN;(3) Department of Molecular Neuropharmacology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland, PL |
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| Abstract: | Summary. To extend our earlier data on synergistic action of tetrahydroisoquinolines and morphine, we have investigated the analgesic effects of 1,2,3,4-tetrahydroisoquinoline (TIQ) and its 1-methyl-(1-MeTIQ) and N-methyl (N-MeTIQ) analogs on analgesia induced by morphine and oxotremorine. 1-MeTIQ and N-MeTIQ induced a moderate, delayed and prolonged analgesic action measured in the tail-flick test in CD-1 mice; 1-MeTIQ and TIQ prolonged the opiate (morphine, 2.5 mg/kg ip) analgesia while TIQ and N-TIQ potentiated cholinergic (oxotremorine, 0.02mg/kg ip) analgesia. The involvement of the opioid and noradrenergic systems in this effect is discussed.Received April 14, 2003; accepted July 9, 2003Published online September 15, 2003 |
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| Keywords: | : Tetrahydroisoquinoline derivatives morphine oxotremorine analgesia mice. |
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