| 青风藤化学成分的分离与鉴定 |
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| 引用本文： | 宋永彬,程维明,曲戈霞,邱峰.青风藤化学成分的分离与鉴定[J].沈阳药科大学学报,2007,24(2):79-81. |
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| 作者姓名： | 宋永彬 程维明 曲戈霞 邱峰 |
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| 作者单位： | 沈阳药科大学,中药学院,辽宁,沈阳,110016 |
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| 摘 要： | 目的对青风藤(Sinomenium auctum (Thunb.) Rehd.et Wils.)化学成分进行分离、鉴定。方法适量干燥青藤茎用10倍量体积分数为70%的乙醇水溶液提取,减压回收乙醇,所得干浸膏研成细粉后,分别用环己烷、氯仿、甲醇超声溶取;采用ODS中低压柱色谱、制备型HPLC方法进行分离,并通过1H-NMR、13C-NMR、ESI-MS等谱学技术对化合物进行结构鉴定。结果分离得到5个化合物,分别鉴定为穆坪马兜铃酰胺(N-trans-feruloyl tyramine,1)、syringaresinol mono-β-D-glucoside(2)、1,2,4/3,5-cyclohexanepentol(3)、3-methoxy-6-hydroxy-17-methylmorphinane(4)、青藤碱(sinomenine,5)。结论化合物1~4为首次从防己属中分离得到。
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| 关 键 词： | 青风藤 防己属 化学成分 |
| 文章编号： | 1006-2858(2007)02-0079-03 |
| 修稿时间： | 2006-04-20 |
Chemical constituents of Sinomenium acutum |
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| SONG Yong-bin,CHENG Wei-ming,QU Ge-xia,QIU Feng.Chemical constituents of Sinomenium acutum[J].Journal of Shenyang Pharmaceutical University,2007,24(2):79-81. |
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| Authors: | SONG Yong-bin CHENG Wei-ming QU Ge-xia QIU Feng |
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| Institution: | School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China |
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| Abstract: | Objective To study the chemical constituents of Sinomenium acutum.Methods The dried stems of Sinomenium acutum were extracted with 70% ethanol and the solvent was removed by rotary evaporation to give an extract.The extract was dissolved in water,and partitioned with cyclohexane,chloroform and methanol,respectively.The constituents were isolated by the silica gel,ODS column chromatography and preparative HPLC,and their structures were confirmed by physico-chemical characters and spectroscopic analysis.Results Five compounds were obtained and identified as N-trans-feruloyl tyramine(1),syringaresinol-monoβ-D-glucoside(2),1,2,4/3,5-cyclohexanepentol(3),3-methoxy-6hydroxy-17-methylmorphinane(4),sinomenine(5).Conclusions Among these compounds,1-4 were isolated from Sinomenium genus for the first time. |
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| Keywords: | Sinomenium acutum(Thunb )Rehd et Wils Sinomenium chemical constituent |
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