| Abstract: | Experiments on mice in which sheep's red cells were used as antigen showed that the height of the secondary immune response of spleen cells in situ or in adoptive transfer is inversely proportional to the dose of red cells used for primary immunization. Cyclophosphamide, injected into the animals simultaneously with the antigen, stimulates the immune response of the mice to the second injection of red cells, but this effect is observed only when comparatively large doses of antigen are used for priming. The mechanisms of this phenomenon are discussed.Laboratory of Immunogenetics, Institute of Medical Genetics, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR N. N. Zhukov-Verezhnikov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 84, No. 9, pp. 336–339, September, 1977. |
