艾滋病治疗的研究进展

艾滋病抗病毒治疗(ART),现已取得很大成效。该病原为致死性疾病,现已成为一种可治可管理的传染病,全球艾滋病病毒感染者/艾滋病(HIV/AIDS)的病例虽仍多达3 800万,但有一半以上已经抗病毒治疗。除了药物治疗外,目前一些新技术新方法如基因组编辑等也已介入艾滋病的治疗,并且在人源化动物试验中业已取得很好的效果。不容置疑,艾滋病终究会被人类控制消除。但随着艾滋病抗病毒治疗的不断发展,最根本的问题也就是HIV潜伏库的问题日益突出,不论是分子治疗、组合治疗都存在这样的问题。因此,不断寻找新的潜伏病毒细胞的标记,缩小病毒潜伏库,是当前艾滋病治疗必须解决的课题。此外,尽管艾滋病的防治取得了很大成绩,但目前全球每天仍有近6 000例HIV/AIDS感染的病例发生。因此,安全有效疫苗的研发,不论在预防领域、还是在临床治疗方面,都有其积极的意义。

Research progress of AIDS treatment

AIDS antiviral therapy (ART) has achieved great success.Originaly,AIDS had been regarded as a fatal disease,but it has become a kind of infectious disease that could be cured and administrated.Global HIV / AIDS cases were still up to about 38 million,but more than half have been effectively treated.In addition to drug treatment,at present,some new technologies and new methods,such as genome editing,have also been involved in the treatment of AIDS,and in the humanized animal experiment has shown very good results.There is no doubt that AIDS will eventually be stopped its epidemic.However,with the continuous development of AIDS antiviral treatment,the most fundamental problem is that HIV latent library has become increasingly prominent one,whether molecular therapy and hybrid cure have being developed for AIDS treatment,there are still such problem existence.Great efforts shoud be made to continuously search for new markers of latent viral cells and to reduce the latent pool.In addition,despite the prevention and treatment of AIDS has made great achievements,but the world still produces nearly 6000 cases of HIV/AIDS every day.Therefore,the development of safe and effective vaccine,whether in the field of prevention,or in clinical treatment,has its positive significance.