Effect of erythropoietin combined with hypothermia on serum tau protein levels and neurodevelopmental outcome in neonates with hypoxic-ischemic encephalopathy |
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Authors: | Hong-yan Lv Su-jing Wu Qiu-li Wang Li-hong Yang Peng-shun Ren Bao-jun Qiao Zhi-ying Wang Jia-hong Li Xiu-ling Gu Lian-xiang Li |
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Affiliation: | 1. Department of Neonatology, Handan Maternal and Child Health Care Hospital, Handan, Hebei Province, China;Department of Neonatal Pathology, Handan Maternal and Child Health Care Hospital, Handan, Hebei Province, China;2. Department of Neonatology, Handan Maternal and Child Health Care Hospital, Handan, Hebei Province, China;3. Department of Children's Rehabilitation, Handan Maternal and Child Health Care Hospital, Handan, Hebei Province, China;4. Department of Neonatal Pathology, Handan Maternal and Child Health Care Hospital, Handan, Hebei Province, China;Department of Neural Development and Neural Pathology, Hebei University of Engineering School of Medicine, Handan, Hebei Province, China |
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Abstract: | Although hypothermia therapy is effective to treat neonatal hypoxic-ischemic encephalopathy, many neonatal patients die or suffer from severe neurological dysfunction. Erythropoietin is considered one of the most promising neuroprotective agents. We hypothesized that erythropoietin combined with hypothermia will improve efficacy of neonatal hypoxic-ischemic encephalopathy treatment. In this study, 41 neonates with moderate/severe hypoxic-ischemic encephalopathy were randomly divided into a control group (hypothermia alone for 72 hours, n = 20) and erythropoietin group (hypothermia + erythropoietin 200 IU/kg for 10 days, n = 21). Our results show that compared with the control group, serum tau protein levels were lower and neonatal behavioral neurological assessment scores higher in the eryth-ropoietin group at 8 and 12 days. However, neurodevelopmental outcome was similar between the two groups at 9 months of age. Thesefindings suggest that erythropoietin combined with hypothermia reduces serum tau protein levels and improves neonatal behavioral neu-rology outcome but does not affect long-term neurodevelopmental outcome. |
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Keywords: | nerve regeneration erythropoietin hypothermia hypoxic-ischemic encephalopathy neonate tau protein biomarkers prognosis neuroprotection neural regeneration |
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