成都市首例人感染H9N2禽流感病例调查与分析

目的总结分析成都市首例人感染H9N2禽流感病例流行病学调查结果,为今后科学应对类似疾病提供参考。方法采用现场流行病学和实验室检测相结合的方法,收集病例临床和流行病学资料,采集并检测病例、相关环境等标本,分析可能的感染来源、流行病学特征和临床特征。结果病例发病前10天内有禽类接触史,其标本经检测为H9N2禽流感病毒阳性;病例长期患有慢性疾病,此次发病后进展较快,经积极治疗无效后死亡;其居住环境、家中剩余鸡肉和周边市场检出H9禽流感阳性。结论该病例感染来源为周边市场感染H9N2禽流感病毒的鸡;对严重基础疾病者,感染H9N2禽流感病毒可导致重症或诱发死亡。

Investigation and analysis of the first cases of human infection with avian influenza A(H9N2) virus in Chengdu,China

We summarized the epidemiological investigation results of the first case of human infection with avian influenza A(H9N2) virus in Chengdu,China,in order to provide references for dealing with similar diseases scientifically in the future.The methods of field epidemiology and laboratory testing were used to collect the H9N2 case's clinical and epidemiological data,as well as collect and test the samples of the H9N2 case and the relevant environment,so that the possible sources of infection,the epidemiological characteristics and clinical features could be analyzed.Results showed that the H9N2 case contacted with poultry within 10 days before the onset of illness and the H9N2 virus nucleic acid was detected in the patient's specimen by PCR.This case suffered from several chronic diseases for a long time,although active treatments were taken this time,she died soon after onset.Her living environment,the chicken leftovers from cooking,and surrounding poultry markets were polluted by H9 avian influenza virus.Through the investigation,we could deduce that the infection source of this case was the chicken infecting H9N2 viruses from surrounding poultry markets.This would be the first fatality associated with influenza A (H9N2) virus infections in humans.And though avian influenza A(H9N2) virus was low pathogenic,infection could cause severe symptoms or death in people with severe underlying diseases.