Aerobic exercise combined with huwentoxin-I mitigates chronic cerebral ischemia injury |
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| Authors: | Hai-feng Mao Jun Xie Jia-qin Chen Chang-fa Tang Wei Chen Bo-cun Zhou Rui Chen Hong-lin Qu Chu-zu Wu |
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| Institution: | 1. Key Laboratory of Physical Fitness and Exercise Rehabilitation of Hunan Province, Hunan Normal University, Changsha, Hunan Province, China;College of Physical Education, Yichun University, Yichun, Jiangxi Province, China;2. College of Physical Education, Yichun University, Yichun, Jiangxi Province, China;3. Key Laboratory of Physical Fitness and Exercise Rehabilitation of Hunan Province, Hunan Normal University, Changsha, Hunan Province, China |
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| Abstract: | Ca2+ channel blockers have been shown to protect neurons from ischemia, and aerobic exercise has significant protective effects on a variety of chronic diseases. The present study injected huwentoxin-I (HWTX-I), a spider peptide toxin that blocks Ca2+ channels, into the caudal vein of a chronic cerebral ischemia mouse model, once every 2 days, for a total of 15 injections. During this time, a subgroup of mice was subjected to treadmill exercise for 5 weeks. Results showed amelioration of cortical injury and improved neurological function in mice with chronic cerebral ischemia in the HWTX-I + aerobic exercise group. The combined effects of HWTX I and exercise were superior to HWTX-I or aerobic exercise alone. HWTX-I effectively activated the Notch signal transduction pathway in brain tissue. Aerobic exercise up-regulated synaptophysin mRNA expression. These results demonstrated that aerobic exercise, in combination with HWTX-I, effectively relieved neuronal injury induced by chronic cerebral ischemia via the Notch signaling pathway and promoting synaptic regeneration. |
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| Keywords: | nerve regeneration chronic cerebral ischemia aerobic exercise huwentoxin-I Notch signaling pathway calcium overload neural regeneration |
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