吸烟、饮酒与食管癌p53基因改变的Meta分析

目的 探讨吸烟、饮酒与食管癌p53基因改变之间的关系。方法 应用Meta分析对有关研究吸烟、饮酒与食管癌p53基因改变的文献进行综合评价。结果 纳入Meta分析的14篇研究吸烟的文献中,吸烟与P53蛋白高表达、p53基因改变(P53蛋白高表达 p53基因突变)的合并OR值分别为1.99(95％CI:1.30～3.06)、1.64(95％CI:1.13～2.37)(P<0.05),吸烟与p53基因突变的合并OR值为1.11(95％CI:0.47～2.76)(P>0.05)。11篇研究饮酒的文献中,饮酒与P53蛋白高表达、p53基因突变和p53基因改变的合并OR值分别为1.30(95％CI:0.83～2.04)、1.13(95％CI:0.67～1.90)和1.22(95％CI:0.87～1.72),合并OR值无统计学意义(P>0.05)。结论 吸烟与p53基因改变有显著联系,饮酒与p53基因改变未见显著联系。

Meta-analysis on the relationship between tobacco smoking,alcohol drinking and p53 alteration in cases with esophageal carcinoma

Objective To investigate the relationship between tobacco smoking,drinking and p53 alteration in esophageal carcinoma. Methods Literature on the relationship between p53 alteration in esophageal carcinoma and tobacco smoking,drinking through Meta-analysis were reviewed. Results In 14 selected papers related to tobacco smoking, pooled odds ratio (OR) of tobacco smoking with P53 overexpression and p53 alteration were 1.99(95% CI: 1.30-3.06) and 1.64(95% CI: 1.13-2.37), respectively (P< 0.05). Pooled OR of tobacco smoking with p53 mutation was 1.11 (95% CI: 0.47-2.76) (P> 0.05 ). In 11 selected papers on alcohol drinking, pooled OR of drinking with P53 overexpression,p53 mutation and p53 alteration were 1.30 (95 % CI : 0.83-2.04 ), 1.13 (95 % CI : 0.67-1.90) and 1.22(95% CI:0.87-1.72) respectively (P>0.05). Conclusion There were significant relations between tobacco smoking and p53 alteration while there were no significant relations between alcohol drinking and p53 alteration.