| 银杏叶提取物辐射防护作用的研究 |
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| 引用本文： | 施雨露,刘照轩,陈强,张小楠,徐效义.银杏叶提取物辐射防护作用的研究[J].中国实验诊断学,2013(11):1973-1974. |
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| 作者姓名： | 施雨露 刘照轩 陈强 张小楠 徐效义 |
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| 作者单位： | [1]吉林大学基础医学院病原免疫细胞遗传实验中心,吉林长春130021 [2]吉林大学药学院再生医学系 ,吉林长春130021 [3]吉林大学公共卫生学院 ,吉林长春130021 [4]吉林大学第一医院肿瘤中心,吉林长春130021 |
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| 摘 要： | 目的利用深部X射线照射小鼠，形成辐射损伤，研究银杏叶提取物对小鼠抗辐射功能的影响。方法通过计算小鼠骨髓细胞的微核率和染色体畸变率来考察银杏叶提取物的辐射防护作用。实验组剂量为5mgL／kg，10mg／kg，20mg／kg，阳性对照组给予生理盐水。结果三种不同剂量的银杏叶提取物均使小鼠的骨髓嗜多染红细胞的微核率及骨髓细胞染色体畸变率有明显的降低（P〈0．01）。结论银杏叶制剂可能通过清除自由基对骨髓细胞产生一定程度的保护作用，而且这种保护作用达到了平台期，呈现相同程度的辐射抗性。
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| 关 键 词： | 银杏叶提取物 抗辐射 微核试验 染色体畸变试验 |
Ginkgo Biloba leaf extract effect of radiation protection |
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| Institution: | SHI Yu-lu ,LIU Zhao-xuan ,CHEN Qiang ,et al. (1. Jilin University Medical Center Hospital Immune Cell Genetic Experiments, Changchun 130021, China;2. J ilin Universi- ty, College of Pharmacy Department of Regenerative Medicine ; 3. J ilin University School of Public Health ) |
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| Abstract: | Objective Using the radiation damage model in mice irradiated with Frays to study the antiradiation function of different dose of Ginkgo Biloba leaf Extract（GBE）. Methods The micronucleus （MN） test and chromo- some aberration （CA） test were applied to evaluate antiradiation protection functions. The experimental groups were given GBE respectively by 5.0 mg/kg, 10.0 mg/kg, 20.0 mg/kg, and the positive control group was given sodium chlo- ride. Results Different dose groups showed significant decrease in both MN test and CA test compared with the posi rive control group （P〈0.01）. Conclusion The BMC protection effect of GBE may be produced by removing free radi- cals,and reach a platform which presented the same antiradiation degree. |
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| Keywords: | GBE radiation protection micronucleus test chromosome aberration test |
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