| 儿童丙戊酸血药浓度与给药剂量 |
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| 引用本文： | 江秀华!650032,张峻!650032,李雪松!650032,周琼!650032. 儿童丙戊酸血药浓度与给药剂量[J]. 儿科药学杂志, 2000, 0(3) |
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| 作者姓名： | 江秀华!650032 张峻!650032 李雪松!650032 周琼!650032 |
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| 作者单位： | 昆明医学院第一附属医院药剂科 |
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| 摘 要： | 目的 研究儿童癫痫服用丙戊酸后血药浓度与给药剂量的关系.方法 对48例癫痫失神性发作儿童患者服用丙戊酸,用荧光偏振免疫法(FPIA)监测血药浓度.结果 达稳态后给药剂量与血药浓度的变化有着密切的关系.结论 监测血药浓度,及时调整给药剂量,对控制儿童患者癫痫失神发作至关重要.
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| 关 键 词： | 丙戊酸 血药浓度 给药剂量 |
The relation between valproic acid dosage and serum concentration in children with epilepsy |
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| JIANG Xiuhau,ZHANG Jun,LIXuesong,ZHOU Qiong. The relation between valproic acid dosage and serum concentration in children with epilepsy[J]. Journal of Pediatric Pharmacy, 2000, 0(3) |
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| Authors: | JIANG Xiuhau ZHANG Jun LIXuesong ZHOU Qiong |
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| Abstract: | Aim To study the relation between dosage and serum concentration of valproic acid in children with epilepsy. Methods The serum concentration of valproic acid of 48 Petit mal children were determined by fluorescence polarization immunoassay(FPLA) . Results The correlaton between dosage and serum concentration is very close after steadystate. Conclusions Monitoring serum concentration and adjusting drug dosage in time are very important for controlling petit mal in children with epilepsy. |
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| Keywords: | Valproic acid Serum concentration Drug dosage |
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