MR加速器在头颈部肿瘤自适应放疗中的临床应用北大核心CSCD

自适应放疗(ART)通过在放疗中适应肿瘤和正常组织轮廓变化从而提高了头颈部肿瘤治疗比。基于MR加速器的MR引导放疗(MRgRT)是目前创新性的头颈部肿瘤ART模式。MR加速器基于MR能实现每日ART, 同时也能在治疗中进行实时MR成像。通过每日ART能明显提高头颈部肿瘤治疗靶区准确性, 更好地避开周围重要危及器官。虽然目前发表的关于MRgRT在头颈部肿瘤ART的临床应用和实施技术的研究逐渐增加, 但总体上这个新型的放疗模式还处于初步发展阶段。本文将对基于MR加速器的MRgRT在头颈部肿瘤ART中的基本原理、临床应用及前景进行综述。

Clinical implementation of MR-Linac systems in adaptive radiation therapy for head and neck cancer

Adaptive radiation therapy (ART) has been proposed as a method to account for changes in head and neck cancer and normal tissues to enhance the therapeutic ratios. Online magnetic resonance-guided radiotherapy (MRgRT) using hybrid MR-Linac systems is a novel innovative application in ART for head and neck cancer. The concept of MR-Linac systems is the ability to acquire MR images for ART and also online imaging during treatment delivery. Daily ART allows to improve the targeting accuracy while avoiding organs at risk for head and neck cancer. Although an increasing number of studies related to clinical application and technical aspect of MRgRT in head and neck cancer have been published, MRgRT for ART of head and neck cancer remains in its infancy. The purpose of this article is to summarize and discuss the rationale, clinical implementation, and prospect of this promising adaptive radiotherapy modality for treating head and neck cancer.