结外NK/T细胞淋巴瘤患者的临床特征及预后分析

目的:探讨结外NK/T细胞淋巴瘤患者的临床特点及预后的影响因素.方法:回顾性分析2009年11月至2019年11月本院收治的结外NK/T细胞淋巴瘤患者的临床资料及实验室指标,同时探索影响生存和预后的因素.结果:共收集到47例具有完整临床资料的结外NK/T细胞淋巴瘤患者,中位发病年龄40(12-82)岁,男性多见,男女比...

Analysis on Clinical Characteristics and Prognosis of 47 Patients with Extranodal NK/T Cell Lymphoma

Objective:To investigate the clinical features and prognostic factors of patients with extranodal NK/T cell lymphoma(ENKTL).Methods:The clinical data of patients with ENKTL from November 2009 to November 2019 was collected and retrospectively analyzed to clarify the clinical features of ENKTL,and evaluate the factors that affected survival and prognosis.Results:Forty-seven patients with ENKTL were collected,median age was 40(12-82) years old,and more common in males than females,at the ratio of 1.47:1.The median follow-up was 28(1-112) months,and 5-year overall survival(OS) rate was 49.3%.The 5-year OS rates of the subjects with ECOG performance stage 0-1 and ≥2 were 51.6% and 0(P=0.001),respectively.The 5-year OS rates of International Prognostic Index(IPI)score 0-1 and ≥2 were 60.0% and 40.6%(P=0.027),respectively.The 5-year OS rates of Ann Arbor staging Ⅰ/Ⅱ and stage Ⅲ/Ⅳ were 61.3% and 31.7%(P=0.005),respectively.The 5-year OS rates of the patients with presentation of B symptoms and without presentation of B symptoms were 79.0% and 30.1%(P=0.013),respectively.The 5-year OS rates of plasma EBV-DNA level <5 × 10~2/ml and ≥5 × 10~2/ml were 60.4% and 33.3%(P=0.003),respectively.The 5-year OS rates of the patients receiving chemotherapy alone,combined chemotherapy and radiotherapy,and chemotherapy followed by autologous hematopoietic stem cell transplantation(auto-HSCT) were12.9%,86.5%,and 62.5%(P=0.001),respectively.Univariate analysis showed that ECOG score,IPI score,Ann Arbor staging,B symptoms,the copy number of EBV-DNA,and treatment regimens were statistically significant for OS.Multivariate analysis showed that ECOG score,B symptoms,the copy number of EBV-DNA,and treatment regimens were independent factors of ENKTL OS.Conclusion:ECOG score,B symptoms,the copy number of EBVDNA,and treatment regimens are independent prognostic factors for OS of patients with ENKTL.