| 大鼠鞘内哇巴因及混合替扎尼定治疗神经病理性疼痛 |
| |
| 引用本文： | 欧阳汉栋,曾维安,李强,何伟雄,王培宗,林丽玲,张志权,刘先国.大鼠鞘内哇巴因及混合替扎尼定治疗神经病理性疼痛[J].南方医科大学学报,2008,28(10):1760. |
| |
| 作者姓名： | 欧阳汉栋 曾维安 李强 何伟雄 王培宗 林丽玲 张志权 刘先国 |
| |
| 作者单位： | [1]华南肿瘤重点实验室／中山大学肿瘤防治中心,广东广州510060 [2]广州医学院附属肿瘤医院,广东广州510095 [3]中山大学中山医学院疼痛研究中心,广东广州510089 |
| |
| 基金项目： | 国家自然科学基金(30571794/C03030301); 广东省科技计划项目(303040077001) |
| |
| 摘 要： | 目的探讨大鼠鞘内畦巴因及混合替扎尼定对神经病理性疼痛的治疗效能。方法雄性SD大鼠250～300g，鞘内留置PE-10导管，1周后制作大鼠脊神经结扎神经病理性疼痛模型。将大鼠随机分组：对照组、哇巴因组、替扎尼定组、畦巴因和替扎尼定混合药物组、育亨宾或阿托品拮抗组，每组6只。测定各组鞘内给药前、给药后各时点的大鼠机械撤足阈值，计算对应时点的最大效应百分比（％MPE），评价抗神经病理性疼痛效果。使用Isobologram分析评价药物的相互作用。结果大鼠鞘内单独注射哇巴因0．25～5μg和替扎尼定0．5～5μg产生剂量依赖性抗神经病理性疼痛的作用（P〈0．05）。Isobologram分析显示大鼠鞘内哇巴因和替扎尼定混合物，两者产生明显的协同效应（P〈0．05）。鞘内阿托品或育亨宾预处理，能够拈抗单独注射哇巴因2．5μg、替扎尼定5μg、哇巴因复合替扎尼定（1／2ED。）的作用（P〈0．05）。结论大鼠鞘内单独注射哇巴因、替扎尼定产生剂量依赖性的抗神经病理性疼痛的作用；鞘内哇巴因混合替扎尼定产生协同作用，其机制可能与中枢α2-肾上腺素受体和胆碱能受体有关。
|
| 关 键 词： | 鞘内 神经病理性疼痛 哇巴因 替扎尼定 |
Effects of intrathecal ouabain and tizanidine injection for treatment of neuropathic pain in rats |
| |
| OU-YANG Han-dong,ZENG Wei-an,LI Qiang,HE Wei-xiong,WANG Pei-zong,LIN Li-ling,ZHANG Zhi-quan,LIU Xian-guo State Key Laboratory of Oncology in Southern China/Cancer Center,Sun Yat-sen University,Guangzhou ,China,Tumor Hospital of Guangzhou Medical College,Guangzhou ,Pain Research Center,Zhongshan School of Medicine,Guangzhou.Effects of intrathecal ouabain and tizanidine injection for treatment of neuropathic pain in rats[J].Journal of Southern Medical University,2008,28(10):1760. |
| |
| Authors: | OU-YANG Han-dong ZENG Wei-an LI Qiang HE Wei-xiong WANG Pei-zong LIN Li-ling ZHANG Zhi-quan LIU Xian-guo State Key Laboratory of Oncology in Southern China/Cancer Center Sun Yat-sen University Guangzhou China Tumor Hospital of Guangzhou Medical College Guangzhou Pain Research Center Zhongshan School of Medicine Guangzhou |
| |
| Institution: | OU-YANG Han-dong1,ZENG Wei-an1,LI Qiang2,HE Wei-xiong1,WANG Pei-zong1,LIN Li-ling1,ZHANG Zhi-quan1,LIU Xian-guo3 1State Key Laboratory of Oncology in Southern China/Cancer Center,Sun Yat-sen University,Guangzhou 510060,China,2Tumor Hospital of Guangzhou Medical College,Guangzhou 510095,3Pain Research Center,Zhongshan School of Medicine,Guangzhou 510089 |
| |
| Abstract: | Objective To investigate the effects of intrathecal ouabain and tizanidine injection for treatment of neuropathic pain in rats.Methods Male SD rats weighing 250-300 g were randomly divided into 5 groups(n=6), namely the control group, ouabain group, tizanidine group, combined ouabain and tizanidine injection group, and the antagonist group.Intrathecal catheter was implanted 7 days before spinal nerve ligation to establish the neuropathic pain model.Mechanical withdrawal threshold(MWT) before and after intra... |
| |
| Keywords: | intrathecal neuropathic pain ouabain tizanidine |
| 本文献已被 CNKI 维普 等数据库收录！ |
| 点击此处可从《南方医科大学学报》浏览原始摘要信息 |
| 点击此处可从《南方医科大学学报》下载免费的PDF全文 |
|
