子痫前期患者血清巨噬细胞集落刺激因子增高的意义

目的:探讨血清巨噬细胞集落刺激因子(MCSF)水平的变化在子痫前期发生与发展中的作用.方法:采用酶联免疫吸附试验(ELISA),测定39例子痫前期(子痫前期组)和40例正常妊娠晚期孕妇(对照组)血清MCSF浓度,比较2组间血清MCSF水平的差异,并比较早发型(34周前发病,15例)和晚发型子痫前期(24例)患者间血清MCSF水平的差异.结果:子痫前期组血清MCSF中位数浓度为431.0 kIU/L,高于对照组的179.1 kIU/L,差异有显著性(P<0.001).早发型和晚发型子痫前期患者血清MCSF水平差异无显著性(P>0.05).子痫前期患者血清MCSF水平与年龄、孕龄、胎盘重量无显著相关性(P均>0.05). 结论:血清MCSF水平增高是子痫前期的重要病理变化,可能与子痫前期的发病有关.

Significance of increased level of serum macrophage colony-stimulating factor in patients with preeclampsia

Objective: To explore the role of macrophage colony-stimulating factor(MCSF) in the pathogenesis of preeclampsia.Methods: By ELISA method,MCSF concentrations were determined in serum samples obtained from 39 patients with preecampsia and 40 normal pregnant women as controls.The concentrations of serum MCSF were compared between preeclampsia and normal pregnancy,and between early-onset and late-onset preeclampsia.Results: Serum MCSF concentrations were significantly higher in preeclamptic women than those in controls(431.0 kIU vs 179.1 kIU,P<0.001).There were no significant differences in serum MCSF levels between early-onset and late-onset preeclampsia(P>0.05).Serum MCSF was not correlated with maternal age,gestational age,and placenta weight(P>0.05 for all).Conclusion: Increased level of serum MCSF is an important indicator of preeclampsia and it may play a role in the pathogenesis of the disease.