| 取代苯甲醛缩二胺类双席夫碱的合成及抗菌活性 |
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| 引用本文： | 杨树平,高乌恩,杨丽敏,刘艳春.取代苯甲醛缩二胺类双席夫碱的合成及抗菌活性[J].内蒙古医学院学报,2004,26(1):7-9. |
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| 作者姓名： | 杨树平 高乌恩 杨丽敏 刘艳春 |
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| 作者单位： | 1. 内蒙古医学院,药学系,内蒙古,呼和浩特,010059
2. 河北宣化通讯士官学校门诊部 |
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| 基金项目： | 内蒙古自治区自然科学基金资助项目 ( No.980 5 3 ) |
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| 摘 要： | 目的：设计合成一系列新的取代苯甲醛缩二胺类双席夫碱，通过抗菌活性测试寻找具有抗菌活性药物。方法：以取代苯甲醛与二胺类经缩合反应，合成席夫碱，并进行体外抑菌活性筛选。结果：合成了8种席夫碱，其结构经元素分析、IR和H^1NMR确证。结论：合成的席夫碱对多种致病菌有明显的抑制作用。
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| 关 键 词： | 取代苯甲醛 席夫碱 二胺类 抗菌活性 |
| 文章编号： | 1004-2113(2004)01-0007-03 |
| 修稿时间： | 2003年10月11 |
SYNTHESIS AND ANTIBACTERIAL ACTIVITIES OF SUBSTITUTED BENZALDEHYDE SEMI-DIAMINES BIS-SCHIFF BASES |
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| YANG Shu-ping,GAO Wu-en,YANG Li-min,et al..SYNTHESIS AND ANTIBACTERIAL ACTIVITIES OF SUBSTITUTED BENZALDEHYDE SEMI-DIAMINES BIS-SCHIFF BASES[J].Acta Academiae Medicinae Neimongol,2004,26(1):7-9. |
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| Authors: | YANG Shu-ping GAO Wu-en YANG Li-min |
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| Abstract: | Objective: A series of novel substituted benzaldehyde diamines Schiff bases were synthesized for screening antibacterical agents. Methods: The Schiff bases were prepared by the condensation reaction of substituted benzaldehyde with diamines. Their antibacterial activities were tested. Results: Eight novel Schiff bases were synthesized and their structures were identified by elementary analysis, IR spectra and H 1NMR. Conclusion: The synthetic Schiff bases have displayed significant antibacterical activities. |
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| Keywords: | substituted benzaldehyde Schiff bases diamines antibacterial activities |
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