新型多孔可吸收骨替代材料修复兔股骨缺损的实验研究

Objective To test the osteogenetic ability and biocompatibility of a new type of porous morsel blocks of resorbable bioglass bone graft substitute. Methods Thirty healthy New Zealand adult white rabbits were selected to establish bone defect models and randomly assigned into 3 even groups(with 20hind legs in each group)for 3 methods of repairing the defects.The 6 mm×10 to 12 mm defeets were made at the bilateral fenloral condyles of each rabbit.In group A,a porous morsel block of resorbable bioactive glass bone substitute was implanted;in group B,commonly used bioactive glass was implanted;in group C,nothing was implanted.Specimens were collected at 6 and 12 weeks after operation to evaluate the biodegradation and osteogenic properties by gross observation, radiography, Micro-CT and histopathological examinations.ResulIs No local adverse reaction was observed in each group.At 6 weeks.gradual growth of the new bone was observed inside the implants in groups A and B.The amount of new bone in group A was significantly higher than in group B.In group A,the porous morsel material was almost completely degraded,bone defects were completely repaired,and bone trabecula moulding reconstruction was completed.In group B,a great amount of material was not completely degraded in the central area of the graft,while bone defects were not healed in the group C.The percentages of new bone area were 0.30±0.02 in group A,0.17±0.03 in group B and 0.06±0.01 in group C,with significant differences(F=374.202,P<0.001).At 12weeks.the percentages of new bone area were 0.53 ±0.05 in group A,0.39±0.05 in group B and 0.07±0.01 in group C,with significant differences(F=317.243,P<0.001). Conclusion New porous morsel blocks of resorbable bioglass bone graft substitute show superior osteogenetic properties and biodegradability because of their good three dimensional structure.

New porous resorbable bone graft substitute to repair femoral defects in rabbits