Intervention of Astragalus membranaceus on radioactive lung injuries and influence on TNF-α and ET expression |
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引用本文: | 奚蕾,夏德洪,沈伟生,周剑波,舒中琴,于波,侯昕珩,王珂.Intervention of Astragalus membranaceus on radioactive lung injuries and influence on TNF-α and ET expression[J].中华放射医学与防护杂志,2010,30(1):327-329. |
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作者姓名: | 奚蕾 夏德洪 沈伟生 周剑波 舒中琴 于波 侯昕珩 王珂 |
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作者单位: | 东南大学医学院附属江阴医院,江阴,214400; |
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基金项目: | 江苏省中医药局中医药科研项目 |
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摘 要: | Objective To observe the lung protection of Astragalus membranaceus against radiotherapy to intermediate-stage and terminal thoracic neoplasm, and its influence on TNF-α and ET expression.Methods The patients with intermediate-stage and terminal thoracic neoplasm under radiotherapy were divided into a treatment group and a control group.Patients in the treatment group took 10 ml of Asragalus membranaceus twice a day.for consecutive 6 months from the beginning of radio therapy.TNF-α and ET in the plasma were measured before and after the radiotherapy.The clinical symptom,iconographic changes and lung diffusion were observed from the 15th day of radiotherapy.Results The TNF-α and ET in plasma afterthe radiotherapy were(2.48±0.75)as/ml and(69.32±23.03)pg/ml for the treatment group,and(5.12±1.01)ns/ml and(97.87±37.83)pg/ml for the control group with the statistial difference(x2=7.49,6.57,P<0.001).The decrease of CO diffusion 5 and 10 months after the radiotherapy in the treatment group was statistically different compared with that in the control group(x2=3.98,3.78,P<0.05).There was a statistical difference of the incidence of acute radiation pneumonitis and pulmonary fibrosis between these two groups(P<0.05).Conclusions Astragalus membranaceus could inhibit the excess expression of TNF-α and ET in plasma and reduce the deterioration of diffusion after radiotherapy,so that it can be used for intervention of lung injuries from radiotherapy.
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关 键 词: | 放射治疗 黄芪 肺损伤 辐射防护 肿瘤坏死因子-α 内皮素 TNF-α |
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