| DEHP染毒后小鼠各脏器含量的测定及其意义 |
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| 引用本文： | 赵文红,厉曙光. DEHP染毒后小鼠各脏器含量的测定及其意义[J]. 中国卫生检验杂志, 2005, 15(3): 262-263,292 |
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| 作者姓名： | 赵文红 厉曙光 |
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| 作者单位： | 1. 蚌埠医学院预防医学系,安徽蚌埠,233001
2. 同济大学医学院,上海,200092 |
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| 基金项目： | 国家自然科学基金资助项目(30271123) |
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| 摘 要： | 目的：探索DEHP(邻苯二甲酸二乙基己酯)在小鼠体内蓄积和分布情况。方法：采用毛细管柱气相色谱一质谱(GC／MS)的选择离子检测方式对染毒小鼠各脏器进行定量分析。结果：染毒小鼠各脏器中检测到DEHP，有剂量一效应关系；并在对照组中也检测到DEHP的存在。结论：DEHP可在动物体内蓄积，对人类可产生潜在危害。
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| 关 键 词： | 小鼠 染毒 脏器 DEHP 含量 动物体内 对照组 蓄积 潜在危害 毛细管柱 |
| 文章编号： | 1004-8685(2005)03-0262-03 |
The detection of organs of mice fed with DEHP and its meaning |
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| ZHAO Wen-hong,Li Shu-guang. The detection of organs of mice fed with DEHP and its meaning[J]. Chinses Journal of Health Laboratory Technology, 2005, 15(3): 262-263,292 |
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| Authors: | ZHAO Wen-hong Li Shu-guang |
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| Affiliation: | Zhao Wen-hong1,Li Shu-guang 2 |
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| Abstract: | Objective:To determine the content of di-2-ethylhexyl phthalate (DEHP)in nice fed DEHP and try to find out its situation of distribution and accumulation in mice.Methods:The selective ion monitoring mode of gas chromatograph/mass spectrometry (GC/MS) was used to analyze qualitatively DEHP and detect the internal organs of mice fed DEHP.Results:DEHP was detected in organs of mice fed DEHP and dose-effect relationship was observed.At the same time DEHP was measured in control mice.Conclusion:DEHP can accumulate in organs of animals and it has possibly potential hazard on human being. [ |
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| Keywords: | DEHP Exposure Mice GC/MS |
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