中药花椒体外抗阴道毛滴虫的作用研究

目的　探讨中药花椒煎剂体外抗阴道毛滴虫的作用。方法　不同药物浓度下对阴道毛滴虫体外培养 ,不同时间观察虫体存活状态 ,并与不同浓度甲硝唑体外抗虫效果进行比较。结果　花椒煎剂浓度为 3 .1 3 % ,即有明显的抗虫效果 ,作用 6 4小时杀虫率可达 85 % ,浓度为 2 5 % ,4小时杀虫率达到 80 .5 % ,8小时达到 1 0 0 %。与甲硝唑抗虫效果比较 ,差异无显著性 (P >0 .0 5 )。结论　中药花椒煎剂是一种有效的抗阴道毛滴虫药物 ,在临床上值得探讨应用

Pharmacological study on antitrichomonal action of Zanthoxylum Bungeanum Maxim

Objective To explore the antitrichomonal effect of decoction from Zanthoxylum Bungeanum Maxim. in culture condition ex vivo.Methods Trichomonas was cultured ex vivo under different concentration of drugs. The survival rate of trichomonas was observed under microscope. The comparison was made with antitrichomonal effect of metronidazole.Results The obvious antitrichomonal effect was observed when concentration of Zanthoxylum Bungeanum Maxim.was as low as 3.13%, and the killing rate for trichomonas was as high as 85% after 64 h. The killing rate was 80.5% and 100% when contacted for 4 h and 8 h, respectively when 25% concentration of Zanthoxylum Bungeaum Maxim.was used. There was no significant difference between the effect of Zanthoxylum Bungeanum Maxim and metronidazole ( P >0.05).Conclusion Zanthoxylum Bungeanum Maxim.has strong killing activity on trichomonas ex vivo and deserves to study and exploit further for its broad application.