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| Fas基因启动子670A／G多态性与脑梗死的关系 | |
| 引用本文： | 应雅韵,傅毅,倪培华,林乐生.Fas基因启动子670A／G多态性与脑梗死的关系[J].检验医学,2009,24(1):21-24. |
| 作者姓名： | 应雅韵 傅毅 倪培华 林乐生 |
| 作者单位： | 1. 上海交通大学医学院附属瑞金医院检验系,上海,200025 2. 上海交通大学医学院附属瑞金医院神经内科,上海,200025 3. 威海市文登市立医院检验科,山东,威海,264400 |
| 摘 要： | 目的了解上海地区汉族脑梗死患者Fas基因-670A／G多态性和等位基因频率的分布情况，探讨其多态性与脑梗死的关系。方法采用聚合酶链反应-限制性片段长度多态性技术（PCR—RFLP），对156例脑梗死患者和95名健康老年人的Fas基因-670A／G位点进行基因分型，计算等位基因的频率分布。结果脑梗死组与老年健康对照组的AA、AG、GG基因型频率分别为28．21％、56．41％、15．38％与42．11％、45．26％、12．63％；A、G等位基因频率分别为56．41％、43．59％与64．74％、35．26％，2组问的差异均无统计学意义（P〉0．05）。脑梗死组的（AG＋GG）型的高密度脂蛋白胆固醇（HDL—C）水平明显低于（AG＋GG）型的健康老年对照组，而低密度脂蛋白胆固醇（LDL—C）水平则明显高于健康老年对照组的（AG＋GG）型，脑梗死组的AA型的三酰甘油（TG）水平明显高于健康老年对照组的AA型，其HDL—C水平明显低于健康老年对照组的AA型。结论Fas基因启动子670A／G位点的单核苷酸多态性与脑梗死的发生无关。 |
| 关 键 词： | Fas 基因多态性 脑梗死 |
The correlation between Fas gene promoter 670A/G polymorphism and cerebral infarction |
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| YING Yayun,FU Yi,NI Peihaa,LIN Lesheng.The correlation between Fas gene promoter 670A/G polymorphism and cerebral infarction[J].Laboratory Medicine,2009,24(1):21-24. | |
| Authors: | YING Yayun FU Yi NI Peihaa LIN Lesheng |
| Institution: | Y1NG Yayun,FU Yi , N1 Peihua , LIN Lesheng ( 1. Department of Laboratory, Ruijin Hospital, Shanghai Jiaotong University School of Medicine ,Shanghai 200025, China; 2. Department of Neurology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China ; 3. Department of Clinical Laboratory, Wendeng City Hospital, Shandong Weihai 264400, China) |
| Abstract: | Objective To investigate the distribution of the genotype and allele frequency of the Fas gene -670A/G single nucleotide polymorphsim （SNP） and evaluate the relationship between the -670A/G SNP and cerebral infarction in Shanghai Hart population. Methods The Fas gene -670A/G was detected by polymerase chain reaction-restriction fragment length polymorphism（PCR-RFLP） technique in 156 cerebral infarction patients and 95 healthy elders. Results The genotypes of the cerebral infarction patients were 28.21% （AA） , 56.41% （AG） and 15.38% （GG）. The genotypes of healthy elders were 42.11% （AA）, 45.26% （AG） and 12.63% （GG）. The allele frequency in cerebral infarction patients was distributed as 56.41% （A） and 43.59% （G） , while in healthy elders was 64.74% （A） and 35.26% （G）. There was no significant difference in genotype and allele frequencies distribution between cerebral infarction patients and healthy elders （ P 〉 0.05 ）. However, the high-density lipoprotein cholesterol（HDL-C） level in cerebral infarction patients was significantly lower than in the healthy elders with genotype of AG and GG. Meanwhile, the lowdensity lipoprotein cholesterol（LDL-C） level in this group was much higher than in the healthy elders. Moreover, the triglyceride（TG） level in cerebral infarction patients was much higher than in the healthy elders, while the HDL-C level was much lower in genotype of AA. Conclusions The Fas gene promoter 670A/G SNP is not associated with cerebral infarction. |
| Keywords: | Fas |
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