| 蛇毒抗高凝状态酶对小鼠骨髓造血系统的影响 |
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| 引用本文： | 朱伟杰,张正明,许力,芮景. 蛇毒抗高凝状态酶对小鼠骨髓造血系统的影响[J]. 皖南医学院学报, 2007, 26(2): 83-84,88 |
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| 作者姓名： | 朱伟杰 张正明 许力 芮景 |
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| 作者单位： | 皖南医学院附属弋矶山医院,普外科,安徽,芜湖,241001 |
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| 基金项目： | 安徽省教育厅自然科学基金 |
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| 摘 要： | 目的:研究蛇毒抗高凝状态酶(AHCSE)对实验性小鼠骨髓造血系统的影响和作用机制。方法:将小鼠随机分为四组,分别用AHCSE,阿霉素,AHCSE+阿霉素,生理盐水经尾静脉注射,10d后观察并测定血清白细胞介素-3(IL-3)含量,骨髓粒细胞比例及粒红比,脾系数。结果:蛇毒抗高凝状态酶能刺激骨髓造血细胞显著增生,血清IL-3含量,骨髓粒细胞比例及粒红比,脾系数AHCSE较其他三组明显增加,有统计学意义(P<0.05)。结论:AHCSE能显著刺激骨髓增生可能与激活细胞免疫机制使细胞因子IL-3增加有关。
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| 关 键 词： | 蛇毒抗高凝状态酶 阿霉素 骨髓造血系统 IL-3 |
| 文章编号： | 1002-0217（2007）02-0083-03 |
| 修稿时间： | 2006-12-05 |
Effects of antihypercoagulability state enzyme of snake venom on bone marrow hematopoietic system in mice |
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| ZHU Wei-jie,ZHANG Zheng-ming,XU Li,RUI Jing. Effects of antihypercoagulability state enzyme of snake venom on bone marrow hematopoietic system in mice[J]. Acta Academiae Medicinae Wannan, 2007, 26(2): 83-84,88 |
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| Authors: | ZHU Wei-jie ZHANG Zheng-ming XU Li RUI Jing |
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| Affiliation: | Department of General Surgery, Yijishan Hospital,Wannan Medical University, Wuhu 241001, China |
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| Abstract: | Objective:To investigate the proliferative effects and mechanism of the antihypercoagulability state enzyme on bone marrow hematopoietic systems in experimental mice.Methods:40 mice were randomly allocated to four groups by intravenous injection of AHCSE,ADM,AHCSE with ADM or normal saline respectively.The contents of interleukin-3(Multi-CSF),percentage of bone marrow granular leukocytes and G/E and spleen body ratio were determined in ten days.Results:AHCSE could stimulate myeloid elements to hyperplasy and increase the granular leukocytes percentage and G/E and spleen body ratio in comparison with the control groups,which had significant statistical difference(P<0.05).Conclusion:AHCSE can obviously stimulate bone marrow hemopoietic systems to hyperplasy,which may be correlated with the interleukin-3 multiplication by active cell immunologic mechanism. |
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| Keywords: | IL-3 |
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