丙泊酚用于神经外科全身麻醉手术患者的药动学研究

目的:研究丙泊酚用于神经外科全身麻醉手术患者的药动学。方法:8名神经外科全身麻醉手术患者静脉注射丙泊酚2mg·kg-1后,用高效液相色谱法测定血清中丙泊酚的浓度。用3p97程序拟合计算药动学参数。结果:静脉注射丙泊酚后的药-时曲线符合三室模型;主要药动学参数t1/2α、t1/2β、t1/2γ分别为(0·8±0·41)、(10·2±15·6)、(113·0±47·2)min,Vc、Vd分别为(0·0548±0·0218)、(2·6482±0·6638)L·kg-1,CL为(17·4±4·5)mL·min-1·kg-1,AUC0～∞为(108·92±31·68)mg·min·L-1。结论:丙泊酚的药动学特征与临床麻醉中迅速分布于全身、起效快、作用时间短、苏醒恢复迅速等特点一致。

Pharmacokinetics of Propofol in Neurosurgical Patients Undergoing General Anesthesia

OBJECTIVE:To study the pharmacokinetics of propofol in neurosurgical patients undergoing general anesthesia.METHODS:8 neurosurgical patients undergoing general anesthesia were assigned to receive propofol iv(2m· kg-1),with their serum concentration of propofol determined by HPLC and pharmacokinetic parameters processed with 3P97 program.RESULTS:The serum concentration-time curve was in line with three compartment model.The pharmacokinetic parameters were the following:t1/2α,t1/2β and t1/2γ were(0.8± 0.41),(10.2± 15.6) and(113.0± 47.2) min,respectively;Vc and Vd were(0.054 8± 0.021 8) and(2.648 2± 0.663 8) L· kg-1,respectively;CL was(17.4± 4.5) mL· min-1· kg-1 and AUC0～ ∞ was(108.92± 31.68) mg· min· L-1.CONCLUSION:Similar to that manifested in clinical anesthesia,the pharmacokinetics of propofol are characterized by rapid distribution throughout body,rapid onset,short duration of action and rapid recovery of consciousness etc.