鼠类慢性高眼压模型的研究进展

青光眼的特征性病变为神经节细胞死亡、视神经变性、视乳头凹陷及进行性的视野缺损.高眼压是青光眼最主要的危险因素之一,因此,国内外的研究者通过建立高眼压动物模型,模拟人类青光眼的主要病理过程,以揭示其发病机制并寻求新的治疗方法.笔者就目前国外研究者对鼠类慢性高眼压模型的建立、模型的评估及模型的应用进行综述,以与眼科同道交流.(中华眼科杂志,2009,45:663-668)

Progress of chronic ocular hypertensive glaucoma in rodents

Glaucoma is characterized by progressive loss of retinal ganglion cell (RGCs), optic nerve atrophy, cupping of the optic disc, and specific visual field deficits. Elevated intraocnlar pressure (IOP) is considered to be a major risk factor associated with the development of this neuropathy, therefore, elevated IOP has been induced in animals to simulate key aspects of human glaucoma, in order to unlock the mechanism of this disease and seek out new therapeutic strategies. In the following review: (1) models used for the study of hypertensive glaucomatous neuropathy in rodents, (2) assessment of these animal models and (3) their usage will be described. (Chin J Ophtbalmol, 2009,45:663-668)