Pulmonary mechanic and lung histology injury induced by Crotalus durissus terrificus snake venom. |
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Authors: | Paula Naomi Nonaka César Ferreira Amorim Ana Claudia Paneque Peres César Augusto Melo E Silva Stella R Zamuner Wellington Ribeiro José Carlos Cogo Rodolfo P Vieira Marisa Dolhnikoff Luis Vicente Franco de Oliveira |
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Affiliation: | Laboratory of Physiology and Pharmacodynamics, Institute of Research and Development-IP&D, University of Vale do Paraiba-UNIVAP, Sao Jose dos Campos, SP, Brazil. |
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Abstract: | In the present work we investigated the effects of Crotalus durissus terrificus venom (CdtV) on the pulmonary mechanic events [static and dynamic elastance, resistive (DeltaP1) and viscoelastic pressures (DeltaP2)] and histology after intramuscular injection of saline solution (control) or venom (0.6 microg/g). The static and dynamic elastance values were increased significantly after 3 h of venom inoculation, but were reduced at control values in the other periods studied. The DeltaP1 values that correspond to the resistive properties of lung tissue presented a significant increase after 6h of CdtV injection, reducing to basal levels 12h after the venom injection. In DeltaP2 analysis, correspondent to viscoelastic components, an increase occurred 12 h after the venom injection, returning to control values at 24 h. CdtV also caused an increase of leukocytes recruitment (3-24 h) to the airways wall as well as to the lung parenchyma. In conclusion, C. durissus terrificus rattlesnake venom leads to lung injury which is reverted, after 24 h of inoculation. |
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Keywords: | Crotalus durissus terrificus Inflammation Respiratory system Lung mechanics |
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