RhoE/Rnd3蛋白在乳腺癌组织中的表达及意义

目的：探讨RhoE/Rnd3蛋白在乳腺癌组织中的表达情况及意义。方法：采用免疫组化方法检测60例乳腺浸润性导管癌、30例正常乳腺组织中RhoE/Rnd3蛋白的表达情况。结果：RhoE/Rnd3蛋白在正常乳腺组织和乳腺癌中的表达率分别为73.3%和40.0%,二者的表达差异具有显著性意义（P〈0.05）RhoE/Rnd3蛋白在乳腺癌中表达与恶性程度呈负相关（P〈0.05）。RhoE/Rnd3的表达与与患者年龄和淋巴结转移呈负相关,与生育史呈正相关。结论：RhoE/Rnd3在乳腺癌的发生中呈负调控作用,RhoE/Rnd3可能通过抑制Cy-clinB1来抑制乳腺癌的发生;RhoE/Rnd3过表达与乳腺癌预后较好有关。

Expression and significance of RhoE/Rnd3 protein in breast carcinoma

Objective： To investigate the expression and significance of RhoE/Rnd3 protein in breast cancer tissue. Methods： The expression of RhoE/Rnd3 protein in breast tissue was detected by immunohistochemistry method in 60 cases of breast primary infiltrating ductal carcinoma,30 cases of normal breast tissue. Results： The positive rates of RhoE/Rnd3 in normal breast tissue and breast cancer were 73.3% and 40.0%,There were significant differences in positive results of RhoE/Rnd3 between normal breast tissue and breast cancer tissue（P0.05）.RhoE/Rnd3 protein was associated negatively with malignant degree of breast carcinoma （P0.05）.The expression of RhoE/Rnd3 was associated negatively with age and lymph node metastasis,positively with fertility. Conclusion： The expression of RhoE/Rnd3 in breast carcinoma is remarkably decreased .RhoE/Rnd3 may inhibit breast carcinoma through suppressing Cyclin B1 protein .The high expression of RhoE/Rnd3 is associated with good prognosis.