三仁汤对脾胃湿热证、湿偏重证大鼠胃动素、胃泌素作用的实验研究

目的：观察三仁汤对脾胃湿热证、湿偏重证大鼠模型血液中胃动素（MTL）、胃泌素（GAS）的调控作用。方法：将32只大鼠随机分为4组各8只。正常对照组：正常温、湿度下予以普通饲料喂养；湿热组：在湿热环境下予以肥甘饮食饲料喂养；湿偏重组：在湿热组饲养基础上灌服北京产二锅头；三仁汤组：在湿偏重组饲养基础上予以三仁汤。采用放免法测定各组大鼠血液中MTL、GAS的变化。结果：MTL、GAS湿热组、湿偏重组与正常对照组、三仁汤组比较，差异均有非常显著性意义（P〈0．01）；湿偏重组与湿热组比较，差异有非常显著性意义（P〈0．01）；三仁汤组与正常对照组比较，差异无显著性意义（P〉0．05）。结论：三仁汤能对抗湿热证大鼠模型血浆胃动素的升高作用，亦具有调节湿热证大鼠模型血浆胃泌素低下的功能。

An Experimental Study of Sanren Tang on Motilin and Gastrin in Damp-Heat and Dominant Damp Syndromes of Spleen - Stomach of Rats

Objective: To observe the regulative action of Sam-en Tang (ST) on motilin (MTL) and gastrin (GAS) in damp - heat and dominant damp syndromes of spleen - stomach of rats. Methods: 32 rats were allocated to 4 groups (each group 8 rats) randomly. The normal control group (NCG) was fed by general feed in normal room temperature and humidity; Damp - heat group (DHG) by greasy feed in wet and hot environment; Dominant damp group(DDG) by greasy feed and rice wine; ST group(STG) by greasy feed , rice wine and ST. The changes of MTL and GAS of blood were determined by radioimmunoassay. Results: The MTL and GAS of DHG and DDG comparied with NCG and STG showing (P<0.01); DDG comparied with DHG showing (P<0.01); STG comparied with NCG showing (P>0.05) . Conclusion: ST possesses the action for counteracting the increase of plasma MTL in models of damp - heat syndrome and regulating the decrease of plasma GAS in rats.