| 卡维地洛对动脉粥样硬化大鼠主动脉谷胱甘肽-S-转移酶Mu1表达的影响 |
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| 引用本文： | 周四喜,袁茜,黄英,宋铁,覃红艳,庄景凡,彭湃. 卡维地洛对动脉粥样硬化大鼠主动脉谷胱甘肽-S-转移酶Mu1表达的影响[J]. 实用预防医学, 2010, 17(8): 1507-1509 |
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| 作者姓名： | 周四喜 袁茜 黄英 宋铁 覃红艳 庄景凡 彭湃 |
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| 作者单位： | 1. 常德职业技术学院医学系机能学教研室,湖南,常德,415000
2. 中山大学中山医学院临床医学系 |
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| 摘 要： | 目的观察卡维地洛对动脉粥样硬化大鼠主动脉谷胱甘肽-S-转移酶Mu1(glutathione S-transferase Mu1,GSTM1)表达的影响,探讨卡维地洛抗动脉粥样硬化的作用机制。方法实验分为正常对照组、动脉粥样硬化模型组、卡维地洛治疗组(卡维地洛10mg/kg.d,连续灌胃6周)。实验结束后,观察大鼠血管形态学变化,检测血清超氧化物歧化酶(SOD)、丙二醛(MDA)含量,观察大鼠主动脉GSTM1表达及活性的变化。结果与正常组比较,动脉粥样硬化模型组血清SOD活性降低,MDA含量增加;与动脉粥样硬化模型组比较,卡维地洛治疗组血清SOD活性明显升高,血清MDA含量明显下降。GSTM1的表达及活性在动脉粥样硬化模型组显著降低,而卡维地洛显著增加了GSTM1的表达及活性。结论卡维地洛具有明显的抗动脉粥样硬化作用,这可能与其增加GSTM1表达,从而增强抗氧化作用,消除氧化应激有关。
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| 关 键 词： | 卡维地洛 动脉粥样硬化 谷胱甘肽-S-转移酶Mu1 |
Effect of Carvedilol on Expression of GSTM1 in Atherosclerosis Rats |
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| ZHOU Si-xi,YUAN Xi,HUANG Ying,et al.. Effect of Carvedilol on Expression of GSTM1 in Atherosclerosis Rats[J]. Practical Preventive Medicine, 2010, 17(8): 1507-1509 |
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| Authors: | ZHOU Si-xi YUAN Xi HUANG Ying et al. |
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| Affiliation: | ZHOU Si-xi,YUAN Xi,HUANG Ying,et al.(Staff Room of Function Experiment,Medical Department,Changde Vocational Technical College,Changde 415000,Hunan,China) |
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| Abstract: | Objective To observe the effect of carvedilol on the expression of glutathione S-transferase Mu 1(GSTM1)in atherosclerosis rats,and to explore the mechanism of carvedilol action in atherosclerosis.Methods There were 3 groups in the experiment:normal control group,atherosclerosis model group,carvedilol treatment group(10 mg/kg.d,for 6 weeks).After the end of the experiment,the change of vascular morphology was observed,and the superoxide dismutase(SOD)activity and malondialdehyde(MDA)level were determined.Th... |
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| Keywords: | Carvedilo Atherosclerosis Glutathione S-transferase Mu 1 |
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