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帕金森病合并抑郁患者认知功能和P300的研究
引用本文:张巧俊,向莉,袁海峰,骞健,傅静,李建刚,吴仲恒,赵英贤.帕金森病合并抑郁患者认知功能和P300的研究[J].临床神经病学杂志,2007,20(3):173-175.
作者姓名:张巧俊  向莉  袁海峰  骞健  傅静  李建刚  吴仲恒  赵英贤
作者单位:1. 710004,西安交通大学第二附属医院神经内科
2. 西安市第四人民医院神经内科
基金项目:陕西省科技攻关项目[2005K13-G6(6)];西安交通大学第二附属医院基金项目(2003-YL-41)
摘    要:目的 探讨帕金森病(PD)合并抑郁患者认知功能和P300的改变。方法 对67例PD患者依据Zung抑郁自评量表(SDS)和汉密顿抑郁量表(HAMD)评分分为PD抑郁组(22例)和PD非抑郁组(45例),分别对两组患者进行认知功能评定和P300检测,并对结果进行比较和相关性分析。结果 本组PD患者简明智力状态量表(MMSE)评分尚在正常范围,但明显低于正常对照组(P〈0.05),PD抑郁组MMSE评分更低(P〈0.01);与正常对照组比较,PD组P300潜伏期延长、波幅降低(均P〈0.05),PD抑郁组改变更为明显(均P〈0.01);PD组P300潜伏期与MMSE评分呈负相关(r=-0.413,P〈0.05),波幅与MMSE评分呈正相关(r=0.398,P〈0.05)。结论 PD患者存在认知功能障碍,以记忆损害最为明显;抑郁对认知功能有负性影响,P300检测可以早期发现PD患者的认知功能障碍。

关 键 词:帕金森病  抑郁  认知功能  P300
文章编号:1004-1648(2007)03-0173-03
收稿时间:2006-07-14
修稿时间:2006-07-142006-10-10

Studies of cognitive function and P300 in depressed patients with Parkinson's disease
ZHANG Qiao-jun, XIANG Li, YUAN Hal-feng,et al..Studies of cognitive function and P300 in depressed patients with Parkinson''''s disease[J].Journal of Clinical Neurology,2007,20(3):173-175.
Authors:ZHANG Qiao-jun  XIANG Li  YUAN Hal-feng  
Institution:ZHANG Qiao-jun, XIANG Li, YUAN Hal-feng, et al.
Abstract:Objective To explore alterations of cognitive function and P300 in depressed patients with Parkinson's disease(PD).Methods Zung's self-rating depression scale(SDS) and Hamilton depression rating scale(HAMD) were used to divide the 67 patients with PD into two groups, PD with depression and PD without depression. The cognitive function and P300 were measured, further comparing and the correlation analysis were made.Results The score of Mini-mental state examination (MMSE) in the PD patients was in normal extent,but significantly lower than that in the normal controls(P<0.05), especially in patients with depression was lower furthermore(P<0.01). Compared with normal control group,the P300 latency was significantly prolonged and the P300 amplitude was significantly lower in PD patients(P<0.05), especially in patients with depression(P<0.01).There was a negative correlation between P300 latency and MMSE score(r=-0.413,P<0.05).There was a positive correlation between P300 amplitude and MMSE score(r=0.398,P<0.05).Conclusions There is cognitive dysfunction in PD patients. Memory impairment is the markedly symptom of cognitive abnormalities in PD patients. There is negative effect of depression on cognitive function. P300 can detect the cognitive dysfunction in early stage of PD patients.
Keywords:Parkinson's disease  depression  cognitive function  P300
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