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| 引用本文： | ????,?????,?????,????.??????????????????????????????????о?[J].中国药学杂志,2016,51(5):386-390. |
| 作者姓名： | ???? ¬???? ????? ???? |
| 作者单位： | 1.??????????????????,???? 510260; 2.?????????????,????510515 |
| 摘 要： | |
| 关 键 词： | ?????? ????? ????????????? ?黯?? ?? |
Preparation and Modification of Capsaicin Solid Lipid Nanoparticles |
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| DUAN Lian,LU Jun-xiong,ZHONG Xun-long,LI Guo-feng.Preparation and Modification of Capsaicin Solid Lipid Nanoparticles[J].Chinese Pharmaceutical Journal,2016,51(5):386-390. | |
| Authors: | DUAN Lian LU Jun-xiong ZHONG Xun-long LI Guo-feng |
| Institution: | 1. The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou 510260, China; 2.Nanfang Hospital, Southern Medical University, Guangzhou 510515, China |
| Abstract: | ??OBJECTIVE To prepare capsaicin-solid lipid nanoparticles (CAP-SLNs) and study their physical and chemical properties. Then, the CAP-SLNs were modified with chitosan (CTS) and the pharmacokinetics across colon of rats was studied in vivo. METHODS CAP-SLNs were prepared by emulsion-solvent evaporation method. The mean size, encapsulation efficiency and drug loading of the nanoparticles were investigated. RESULTS The average diameter of CAP-SLNs was (118.89??25.0) nm, the encapsulation efficiency was (38.56??2.6)%, and the drug-loading was (6.17??0.21)%. After colon-specific delivery in rats, the AUC0-360 min(243.63??61.46) mg??min??L-1 and ??max(1.23??0.18) mg??L-1 of CTS-CAP-SLNs were 1.81-fold and 1.95-fold higher than CAP. CONCLUSION It is simple and feasible to prepare CAP-SLNs by emulsion-solvent evaporation method. The pharmacokinetic parameters in rats are improved remarkably compared with CAP. |
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