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| 引用本文： | ����,���ѱ�,������,������,������,��.��ɷ�ת�;�ƻ��������֦����Ʊ��������о�[J].中国药学杂志,2016,51(8):645-649. |
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| 作者姓名： | ���� ���ѱ� ������ ������ ������ �� |
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| 作者单位： | ????????????, ???? 710032 |
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| 摘 要： |
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| 关 键 词： | ???????? ??????? ????? pH???? ??????? |
Nanoconjugate of 2,3-Dimethylmaleic Anhydride-Decorated Polyethyleneimine-Poly(��-L-Malic Acid)-Doxorubicin: Preparation,Characterization and Biological Evalution |
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| ZHOU Qing,QIAO You-bei,GUO Song-yan,CUI Ming-feng,WANG Yu-kun,WU Hong.Nanoconjugate of 2,3-Dimethylmaleic Anhydride-Decorated Polyethyleneimine-Poly(��-L-Malic Acid)-Doxorubicin: Preparation,Characterization and Biological Evalution[J].Chinese Pharmaceutical Journal,2016,51(8):645-649. |
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| Authors: | ZHOU Qing QIAO You-bei GUO Song-yan CUI Ming-feng WANG Yu-kun WU Hong |
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| Institution: | Department of Pharmaceutical Analysis, School of Pharmacy, The Fourth Military Medical University, Xi??an 710032, China |
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| Abstract: | ??OBJECTIVE To synthesize the biomacromolecule of poly-malic acid (PMLA) for preparation of a novel 2,3-dimethylmaleic anhydride-decorated polyethyleneimine-poly(??-L-malic acid)-doxorubicin nanoconjugate for effective and specific drug delivery. METHODS The structures of PMLA and the nanoconjugate were confirmed by 1H-NMR. Then the conjugation efficiency and drug release property were determined. The cellular uptake and cytotoxicity were assessed by using human hepatocellular carcinoma (HCC) cell line Huh7 as in vitro cell model. RESULTS PMLA and DOX/PMLA-PEI-DMA were successfully prepared. The nanoconjugate possessed pH-sensitive charge-conversion and pH-dependent drug release properties. DOX/PMLA-PEI-DMA enhanced the cellular uptake of DOX and in vitro cytotoxicity effectively. CONCLUSION Nanoconjugate DOX/PMLA-PEI-DMA can be used as a promising drug carrier for its targeted and intracellular delivery. |
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