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Optimization for Preparation Process of Fanhuncaoin Dry Powder for Inhalation

??OBJECTIVE To optimize the preparation process conditions of fanhuncaoin dry powder for inhalation by orthogonal design. METHODS Fanhuncaoin dry powder was prepared by spray-drying method. Following spray-drying, particle size analysis was performed by laser diffraction. Resultant powders were characterized using scanning electron microscopy. The aerosolisation performance was determined using twin-stage liquid impinger. And moisture content was examined by thermogravimetric analysis. The preparation process conditions were optimized with orthogonal design combined with multi-index test. The powder yield, aerodynamic diameter, moisture content and respirable fraction were used as indices for orthogonal design. RESULTS The results of optimized process parameters were confirmed with atomization pressure of 210 kPa, feed flow rate of 9.1 mL??min^-1, aspiration speed of 0.6 m³??min^-1 and inlet temperature of 130 ??. As a result,51.19% yield, 2.92 ??m aerodynamic diameter,4.18% moisture content and 54.45% respirable fraction are obtained by the optimal process conditions. CONCLUSION Orthogonal design combined with multi-index test can be used to optimize the preparation process of fanhuncaoin dry powder for inhalation.