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Effect of Solvent pH on Properties and Clinical Use of Four Drugs in Gynecology and Obstetrics

??OBJECTIVE To investigate the effect of solvent pH on the physical/chemical properties and clinical use of four drugs commonly used in gynecology and obstetrics, including aminophylline, ambroxol, labetalol and ritodrine, through simulation and evidence-based evaluation to provide theoretical guidance and quantitative reference for clinical use. METHODS By searching PubMed compound and Martindale:The Complete Drug Reference, the physical/chemical and clinical information of the four drugs were obtained. The logP, pK_a, logD, and solubility were simulated using ACD/LAB 6.0 software. RESULTS The solvent pH had effects on the logD and solubility of the four drugs to a certain degree in an exponential manner. The four drugs are compatible with dextrose injection or 0.9% sodium chloride injection, but special care needs to be taken in the clinical use. CONCLUSION Solvent pH has influence on the dissolution balance of the four drugs. Simulation of the physical/chemical properties of drugs will provide theoretical guidance and reference for clinicians with more detailed information.