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| 引用本文： | ������,���,�ν��,����Ⱥ,��ǿ.���ػ��Ž�����������ض�����ǵ����⿹�������о�[J].中国药学杂志,2015,50(24):2130-2134. |
| 作者姓名： | ������ ��� �ν�� ����Ⱥ ��ǿ |
| 作者单位： | 1.?????????, ???? ???? 475004; 2.????? ???? 510006 |
| 摘 要： | |
| 关 键 词： | ????? ??????????? ??????? ?????? |
In Vitro Anticancer Activity of Doxorubicin-loaded Heparinized Magnetic Mesoporous Silica Nanoparticles |
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| WANG Hai-yan,FENG Sa,REN Jie-jie,LIU Chao-qun,WU Qiang.In Vitro Anticancer Activity of Doxorubicin-loaded Heparinized Magnetic Mesoporous Silica Nanoparticles[J].Chinese Pharmaceutical Journal,2015,50(24):2130-2134. | |
| Authors: | WANG Hai-yan FENG Sa REN Jie-jie LIU Chao-qun WU Qiang |
| Institution: | 1.Pharmaceutical College of Henan University, Kaifeng 475004, China; 2.Guangdong Pharmaceutical University, Guangzhou 510006, China |
| Abstract: | ??OBJECTIVE To prepare doxorubicin-loased heparinized magnetic mesoporous silica nanoparticles (MMSNs-HP) and investigate their drug release profile and anticancer activity in vitro. METHODS Amino-modified MMSNs was synthesized by combining phase transfer method with sol-gel method firstly. Then heparin was conjugated with the above nanoparticles via carbodiimide chemistry to form MMSNs-HP. Finally, the following experiments were performed, such as loading/release of doxorubicin into/from MMSNs-HP in vitro, cellular uptake of MMSNs-HP by hepatoma cell HepG2 and cell cytotoxicity of doxorubicin-loaded MMSNs-HP. RESULTS MMSNs-HP was able to delay the release of doxorubicin significantly, penetrate into tumor cells, kill HepG2 cell, and inhibit the proliferation of HepG2 cells induced by basic fibroblast HepG2 cells (bFGF). CONCLUSION MMSNs-HP is a potential drug carrier for the delivery of antitumor drugs. |
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