Bilateral choroidal osteoma with unilateral polypoidal choroidal vasculopathy treated with conbercept |
| |
Authors: | Yan-Ming Huang Li Zhang Jin Liang and Rong-Di Yuan |
| |
Institution: | Department of Ophthalmology, Zhongda Hospital Southeast University, Nanjing 210000, Jiangsu Province, China |
| |
Abstract: | Ischemic and neovascular diseases are one of the most difficult ocular diseases to deal with nowadays. Redundancy, poor visual acuity and decreased life quality are bothering patients and ophthalmologists for decades. After VEGF was found to be a primary factor in promoting retinal angiogenesis, intravitreal injection of anti-VEGF drugs has been the first-line treatment. Whereas, some patients are refractory to this therapy and problems of economic burden, local complications and adverse effects promote researches into other possible targets. The vasohibin (VASH) family is a newly-investigated factor in modulating ocular angiogenesis. The family includes VASH1 and VASH2, which show opposite effects of inhibiting and accelerating angiogenesis respectively. Positive results have been reported in cellular and animal experiments. With further researches, it can be a promising future target of treating ocular neovascular diseases. |
| |
Keywords: | vasohibin ocular neovascularization retinal neovascularization |
本文献已被 维普 等数据库收录! |
| 点击此处可从《国际眼科杂志(英文版)》浏览原始摘要信息 |
| 点击此处可从《国际眼科杂志(英文版)》下载免费的PDF全文 |