| 5�ַ��鹤�ն���ȥ�����ὺ�������ܳ���Ӱ�� |
| |
| 引用本文： | ��ٻ,���. 5�ַ��鹤�ն���ȥ�����ὺ�������ܳ���Ӱ��[J]. 中国药学杂志, 2016, 51(23): 2037-2040. DOI: 10.11669/cpj.2016.23.012 |
| |
| 作者姓名： | ��ٻ ��� |
| |
| 作者单位： | ??????????????????ι??, ???? 710077 |
| |
| 摘 要： |
|
| 关 键 词： | ????????? ???鷽?? ????????? ????????? |
Effects of Different Grinding Methods on in Vitro Dissolution of Ursodeoxycholic Acid Capsules |
| |
| DING Qian,TANG Liu. Effects of Different Grinding Methods on in Vitro Dissolution of Ursodeoxycholic Acid Capsules[J]. Chinese Pharmaceutical Journal, 2016, 51(23): 2037-2040. DOI: 10.11669/cpj.2016.23.012 |
| |
| Authors: | DING Qian TANG Liu |
| |
| Affiliation: | New Drug Research Institute,Xi'an Lijun Pharmaceutical Co., Ltd.,Xi'an 710077, China |
| |
| Abstract: | ??OBJECTIVE To compare the in vitro dissolution of ursodeoxycholic acid capsules prepared by different grinding METHODS and screen the best grinding method. METHODS Using the large cup method, HPLC was used to investigate the similarity of dissolution behaviors between the reference preparation Ursofalk? (the original drug) and the self-made ursodeoxycholic acid capsules in four dissolution media. The grinding method which obtained product with qualified similarity factor f2 was determined as the best technology. RESULTS The ursodeoxycholic acid capsules made with raw material micronized by ball grinder for 3 min had similar dissolution curve to the original drug. CONCLUSION Rational preparation process is established for ursodeoxycholic acid capsules. |
| |
| Keywords: | |
|
| 点击此处可从《中国药学杂志》浏览原始摘要信息 |
|
点击此处可从《中国药学杂志》下载全文 |
